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IRCT138902113843N1 IRCT 2010-12-01 Ahvaz Jundishapur University of Medical Sciences Negative symptom treatment in schizophrenia disorder Evaluation of Typical Antipsychotic Augmentation with citalopram in reduction of Negative Symptoms in Inpatient schizophrenia in Ahvaz Golestan Hospital 1389 2010-08-23 anticipated 40 Complete https://irct.ir/trial/3968 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Schizophrenia disorder. Intervention 1: citalopram 20mg on the 1st till 7th days, then 40mg on 8th till 42 days. Intervention 2: placebo 1tablet on the 1st till 7th days, then 2 tablets in 8th till 42 days.
public Dr Niloufar Khajeddin
Golestan Blv
Ahvaz Iran (Islamic Republic of) +98 61 1374 3038 khajeddinn@gmail.com Ahvaz Jundishapor University of Medical Sciences scientific Dr Niloufar Khajeddin
Golestan Blv
Ahvaz Iran (Islamic Republic of) +98 61 1374 3038 khajeddinn@gmail.com Ahvaz Jundishapor University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Diagnosis of schizophrenia based on DSM-IV TR structured clinical interview by a psychiatrist (faculty member and psychiatry resident), prominent negative Symptoms (PANSS negative score more than 15) , total PANSS score more than 50, no liver disease, no treatment with ECT within 6 months, age between 18 and 70, illness duration at least 1 year. Exclusion criteria: depressive disorder based on DSM-IV TR interview and more than 17 score by Hamilton depression rating scale , MR, schizoaffective, Bipolar disorder, Neurological disorders , severe organic disease for example IHD or CHF, treatment with anti depressants or lithium, deaf mute, substance abuse within 1 month ago (except nicotine and caffeine), use of any other drugs which had interactions with this study, active suicidal or homicidal thoughts, breast feeding or pregnancy, past history of allergy or complications with study medication, EPS, at least 3 months interval with the last dose of long term antipsychotic medication 18 years 70 years Both F20 paranoid schizophrenia, hebephrenic schizophrenia, catatonic schizophrenia ,undiffrentiated schizophrenia Treatment - Drugs Treatment - Drugs citalopram 20mg on the 1st till 7th days, then 40mg on 8th till 42 days. placebo 1tablet on the 1st till 7th days, then 2 tablets in 8th till 42 days. Positive symptoms, negative symptoms, general psychopatology. Timepoint: Days 0, 21, and 42. Method of measurement: PANSS scale. Extrapyramidal side effects. Timepoint: Days 0, 21, and 42. Method of measurement: SIMPSON ANGUS SCALE. Ahvaz Jundishapur University of Medical Sciences Approved Ahvaz Jundishapor University of Medical Sciences Golestan Blvd., Ahvaz Ahvaz Iran (Islamic Republic of)