IRCT20100427003813N6 IRCT 2018-05-10 Babol University of Medical Sciences evaluation of applying Plasma rich growth factor(PRGF) with Metformin gel 1% in treating periodontal intrabony defects Clinical and radiographic evaluation of applying Plasma rich growth factor(PRGF) with Metformin gel 1% in treating periodontal two-walls intrabony defects 2017-04-20 anticipated 24 Complete https://irct.ir/trial/3935 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple, Blinding description: patients do not aware of treatment group which they included outcome measurer is different from whom that cures patients. 3 Chronic periodontitis. Intervention 1: interventional group:open flap debridement with metformin gel 1%. Intervention 2: Intervention group 2: open flap debridement with plasma-rich growth factor. Intervention 3: Intervention group 3: Open flap debridement with metformin gel 1% and plasma-rich growth factor. Intervention 4: Control group: Open flap debridement. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information