IRCT20190503043454N1 IRCT 2019-07-06 Tehran University of Medical Sciences Efficacy of platelet_rich plasma on embryo implantation Efficacy of intrauterine infusion of platelet_rich plasma on pregnancy outcome in patients with repeated implantation failure. 2019-05-22 anticipated 120 Complete https://irct.ir/trial/39289 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Balanced Block Randomization (Block size=4): We prepare four balls,two A and two B.for first patient ,a nurse who does not know our plan for both A and B groups, selects one ball randomly from basket.for next patient this selection were done through remaining three balls.for third patient from remaining two balls and the last ball for the fourth patient, and then another block was selected.therefore our blocks show one of these pattern. (BAAB) (BABA) (ABBA) (BBAA) (ABAB) (AABB). N/A Repeated Implantation Failure. Intervention 1: Intervention group:48 hours before embryo transfer (ET), 20 ml of peripheral venous blood will be obtained by syringe pre-filled with 2ml of Acid Citrate A anticoagulant solution(Royagen),and then will be centrifuged immediately at 170 g for 10 minutes to separate red blood cells.this plasma will be re_centrifuged at 340 g for 5 minutes to obtain platelet-rich plasma (PRP), that contained platelet 4-5 times more than peripheral blood. 0.5ml of PRP will be infused into the uterine cavity with IUI catheter and after 48 hours, ET will be done with IUI catheter(Takwin,Iran). Intervention 2: Control group: ET will be done with IUI catheter without intrauterine infusion of PRP. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.