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IRCT20180811040759N1 IRCT 2019-09-09 Rafsanjan University of Medical Sciences The effect of topical Pistacia vera oil on knee joint osteoarthritis The effect of topical Pistacia vera oil on clinical signs and symptom of knee joint osteoarthritis: a randomized and double blind clinical trial 2019-03-21 anticipated 75 Complete https://irct.ir/trial/39262 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization method. Unit: individual, simple random instrument: dice throwing one and two numbers for group A and numbers three and four for group B and numbers five and six for group C and completing groups with this sequence. And hiding using randomly encoded boxes, Blinding description: To have double blind study, before the study begins, the drugs will be packaged by someone other than the researcher in the same packages and encoded as A, B, and C.Prescribing by rheumatologist as an A or B or C drug and Delivery is done by someone else. 3 Osteoarthritis. Intervention 1: Intervention group: Group A is used topically in the pyroxicam gel. The treatment duration is 3 months and twice daily. During the study, patients are only allowed to use oral analgesics (7.5 mg of meloxicam) once daily in all groups if needed, and none of the common drugs will be used during this period. Intervention 2: Intervention group: Group B is used topically for pistachio oil. The treatment duration is 3 months and twice daily. During the study, patients are only allowed to use oral analgesics (7.5 mg of meloxicam) once daily in all groups if needed, and none of the common drugs will be used during this period. Intervention 3: Control group: Group C is used topically from the base of Farabi, which is a ready-made and non-effective drug base, along with color for placebo. The treatment duration is 3 months and twice daily. During the study, patients are only allowed to use oral analgesics (7.5 mg of meloxicam) once daily in all groups if needed, and none of the common drugs will be used during this period. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Fateme nazhadkoorki
Ali ibn Abi Talib Square, Ali ibn Abi Talib Hospital
Rafsanjan Iran (Islamic Republic of) 7717933777 +98 34 3428 0038 fatemenezhadi@gmail.com Rafsanjan University of Medical Sciences scientific Fateme nezhadkoorki
Ali ibn Abi Talib Square, Ali ibn Abi Talib Hospital
Rafsanjan Iran (Islamic Republic of) 7717933777 +98 34 3428 0038 fatemenezhadkoorki@gmail.com Rafsanjan University of Medical Sciences Iran (Islamic Republic of) age 45-70 years diagnosis of knee osteoarthritis according to American College of Rheumatology, approved by rheumatology specialist the average knee pain within 24 hours is based on the linear-visual pain scale (VAS) between 4 to 7 45 years 70 years Both Patients with inflammatory diseases (such as lupus, rheumatoid arthritis, history of brucellosis, etc.) cancer or chronic diseases symptoms or history of liver or kidney failure oral corticosteroid consumption during the past 4 weeks corticosteroid injection in the last 6 months fever Consumption of medical herbs continuously Smoking pistachio allergy use of food and drug supplements Oral use of other analgesics and other compounds effective in treating osteoarthritis up to 10 days before the study Skin or infectious disease or ulcer at the place of administration pregnancy M17 Osteoarthritis of knee Treatment - Drugs Treatment - Drugs Placebo Intervention group: Group A is used topically in the pyroxicam gel. The treatment duration is 3 months and twice daily. During the study, patients are only allowed to use oral analgesics (7.5 mg of meloxicam) once daily in all groups if needed, and none of the common drugs will be used during this period. Intervention group: Group B is used topically for pistachio oil. The treatment duration is 3 months and twice daily. During the study, patients are only allowed to use oral analgesics (7.5 mg of meloxicam) once daily in all groups if needed, and none of the common drugs will be used during this period. Control group: Group C is used topically from the base of Farabi, which is a ready-made and non-effective drug base, along with color for placebo. The treatment duration is 3 months and twice daily. During the study, patients are only allowed to use oral analgesics (7.5 mg of meloxicam) once daily in all groups if needed, and none of the common drugs will be used during this period. Knee pain intensity. Timepoint: At the beginning and the end of the study (three months after the beginning of the study). Method of measurement: The linear-visual scale of pain. Morning stiffness & Patients' function. Timepoint: At the beginning and the end of the study (three months after the beginning of the study). Method of measurement: WOMAC questionnaire. Rafsanjan University of Medical Sciences Approved 2019-01-01 Ethics Committee of Rafsanjan University of Medical Sciences Ali ibn Abi Talib Square, Ali ibn Abi Talib Hospital Rafsanjan Kerman Iran (Islamic Republic of)