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IRCT20190430043425N1 IRCT 2019-05-16 Qazvin University of Medical Sciences Medical Treatment with Aloevera Gel in Chronic Anal Fissure Comparison of Internal Sphincterotomy and Medical Treatment with Aloevera Gel in Chronic Anal Fissure 2019-05-22 anticipated 50 Complete https://irct.ir/trial/39184 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization with Win Pepi. 2-3 Chronic anal fissure. Intervention 1: Control group: Internal sphincterotomy. This method is an operation performed on the internal anal sphincter muscle. The procedure helps by lowering the resting pressure of the internal anal sphincter, which improves blood supply to the fissure and allows faster healing. Intervention 2: Intervention group: Medical treatment with Aloevera gel. Aloevera gel as much as a knuckle three times a day. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Davoud Karimzadeh Aghda
Shahid Bahonar Blvd
Qazvin Iran (Islamic Republic of) 3419915315 +98 28 3333 6001 davoud.karim65@gmail.com Qazvin University of Medical Sciences scientific Zahra Farahaninik
Taavon Sqare, 22 Bahman Blvd, Minoodar, Velayat Educational and Treatment Center
Qazvin Iran (Islamic Republic of) 3419915315 +98 28 3379 0622 dr.zfarahaninik@gmail.com Qazvin University of Medical Sciences Iran (Islamic Republic of) Patients with chronic fissure that require treatment. no limit no limit Both Diabetes Crohn's disease Ulcerative colitis Cancer Pregnancy K60.1 Chronic anal fissure Treatment - Surgery Treatment - Other Control group: Internal sphincterotomy. This method is an operation performed on the internal anal sphincter muscle. The procedure helps by lowering the resting pressure of the internal anal sphincter, which improves blood supply to the fissure and allows faster healing. Intervention group: Medical treatment with Aloevera gel. Aloevera gel as much as a knuckle three times a day. Comparison of internal sphincterotomy and medical treatment with Aloevera gel in itching of chronic anal fissure. Timepoint: Two, four and six weeks after treatment. Method of measurement: The itching score is defined from 0 lack of itching up to 4 very severe itching. Comparison of internal sphincterotomy and medical treatment with Aloevera gel in bleeding of chronic anal fissure. Timepoint: Two, four and six weeks after treatment. Method of measurement: Permanent bleeding after defication means high bleeding, bleeding occasionally during defication means middle bleeding and the presence of thin transparent blood without bleeding during defication means that the bleeding is low and the absence of bleeding, for at least 5 days, means no bleeding. Comparison of internal sphincterotomy and medical treatment with Aloevera gel in the pain of chronic anal fissure. Timepoint: Two, four and six weeks after treatment. Method of measurement: The complete absence of pain means relief in pain and having any rate of pain means no relief in pain. Comparison of internal sphincterotomy and medical treatment with Aloevera gel in wound healing of chronic anal fissure. Timepoint: Two, four and six weeks after treatment. Method of measurement: Full recovery of wound means anoderm healing without scarring and inflammation, relative healing of the wound means reducing inflammation and swelling of the wound, lack of wound healing means remaining the wound or worsening as abscess or fistula. Qazvin University of Medical Sciences Approved 2018-11-20 Ethics committee of Qazvin University of Medical Sciences Shahid Bahonar Blvd, Vice chancellor for research Qazvin Qazvin Iran (Islamic Republic of)