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IRCT20190423043359N1 IRCT 2019-08-15 Razi University Effect of aerobic training and vitamin D supplementation on liver Fat, liver enzymes and lipid profile Effect of aerobic training and vitamin D supplementation on liver Fat, liver enzymes and lipid profile in elderly women with nonalcoholic fatty liver and vitamin D deficiency 2018-12-12 anticipated 40 Complete https://irct.ir/trial/39065 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Factorial, Purpose: Health service research, Randomization description: Forty subjects will be randomly divide into four groups includes Aerobic training (AT, n=10); Vitamin D supplementation (Vit D, n=10); Aerobic training with vitamin D supplements (AT+Vit D, n=10); and control (C, n=10) using statistical software. Each participant will have an equal chance of being in each group, and researchers and participants in the study will not be able to predict the type of intervention they receive. 1 Non-alcoholic fatty liver disease. Intervention 1: The aerobic training + vitamin D supplementation Intervention will be consists of 20-40 minutes of aerobic exercise at 60% - 75% of HRmax, 3 times a week for eight weeks and vitamin D supplementation will be receiving vitamin D (∼50000 IU • week for eight weeks). Intervention 2: Intervention group: Aerobic training consists of 20-40 minutes of aerobic exercise at 60% - 75% of HRmax, 3 times a week for eight weeks. Intervention 3: Intervention group: Vitamin D supplementation includes receiving vitamin D (∼50000 IU • week for eight weeks). Intervention 4: Control group: receiving placebo and no aerobic training for eight weeks. Yes - There is a plan to make this available What will be shared: All data will be record in the SPSS software and will be available. When: Availability will start nine months after publishing all papers To whom: Only available for researchers in academic and scientific institutions Conditions: All data can be used as reference Where to obtain: Zahra.hoseinir@gmail.com How to obtain: If the explanation for data request would be convincing it will be given in 3 days. Comments: not having any
public Rastegar Hoseini
No.9, Taqh-Bostan Ave, University Blvd, Razi University.
Kermanshah Iran (Islamic Republic of) 6714967346 +98 83 3428 3272 Rastegar.hoseini@gmail.com Razi University scientific Rastegar Hoseini
Bagh-abrisham Blvd, Razi University
Kermanshah Iran (Islamic Republic of) 6714967346 +98 988334233267 Rastegar.hoseini@gmail.com Razi University Iran (Islamic Republic of) Ultrasound (US) confirmation of being in second or third grade of NAFLD and certified by an internist 25-OHD serum levels between 10 and 20 ng/ml Being in second or third grade of NAFLD Not having a specific diet and regular exercise program in the past year 60 years 65 years Female Significant consumption of alcohol more than 20 gr per day Presence of other liver diseases (B and C hepatitis) Other disorders such as autoimmune hepatitis, joint disease, celiac and Wilson disease, coronary artery disease, kidney failure, hypothyroidism Surgical treatment of obesity or severe weight loss Presence of any other chronic disease or skeletal disorders K76.0 Fatty (change of) liver, not elsewhere classified Lifestyle Lifestyle Lifestyle Other The aerobic training + vitamin D supplementation Intervention will be consists of 20-40 minutes of aerobic exercise at 60% - 75% of HRmax, 3 times a week for eight weeks and vitamin D supplementation will be receiving vitamin D (∼50000 IU • week for eight weeks). Intervention group: Aerobic training consists of 20-40 minutes of aerobic exercise at 60% - 75% of HRmax, 3 times a week for eight weeks. Intervention group: Vitamin D supplementation includes receiving vitamin D (∼50000 IU • week for eight weeks). Control group: receiving placebo and no aerobic training for eight weeks Liver fat levels. Timepoint: Evaluation of fatty liver grade prior to the intervention and 24-48 h after intervention finished. Method of measurement: Using ultrasound (US). Vitamin D levels. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By blood sampling. Anthropometric indices. Timepoint: Before the study starts and after the study ends. Method of measurement: Using INBODY test. Lipid profile. Timepoint: Before the study starts and after it ended. Method of measurement: Blood sampling. Serum levels of liver enzymes. Timepoint: Before the study starts and after it ended. Method of measurement: Blood sampling. Glucose and insulin levels. Timepoint: Before the study starts and after it ended. Method of measurement: Blood sampling. Blood pressure. Timepoint: Before the study starts and after it ended. Method of measurement: Digital sphygmomanometer. Razi University Approved 2019-03-06 Ethics committee of Kermanshah University of Medical Sciences No. 8, Beheshti Blvd, Kermanshah Province, Kermanshah University of Medical Sciences. Kermanshah Kermanshah Iran (Islamic Republic of)