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IRCT20190410043231N1 IRCT 2019-07-13 Arak University of Medical Sciences Comparing the effect of Dexmedetomidine and Remifentanil for induction of controlled hypotension during rhinoplasty Comparing the effect of Dexmedetomidine and Remifentanil of induce controlled hypotension during rhinoplasty 2019-04-27 anticipated 60 Complete https://irct.ir/trial/39036 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple individual randomization with envelopes in three groups A and B and C.‏ In this method, some cards will be signed as intervention group1 and the same ‎number of cards for intervention group 2 and the same ‎number of cards for the control group, then the cards will be mixed. One card will be taken out and its ‎group name will be registered and then card will be returned to the container again. Then the cards ‎will be mixed again and another card will be taken. This process will be continued to reach a random sequence ‎according to sample size.‏, Blinding description: This study is double blind. Researcher who complete questionnaire and analyzer and participant will be blind (double blind). Outcome assessor and analyzer and participants will not be aware from grouping.The person evaluating the outcome will be unaware of the grouping. Definition of groups A and B will be available to analyzer and outcome assessor. 1-2 Rhinoplasty. Intervention 1: Intervention group 1: Dexmedetomidine, 0.5 micro grams per kilogram per hour for infusion during surgery. Intervention 2: Intervention group 2: Remifentanil 50 to100 micro grams per kilogram per hour for infusion during surgery. Yes - There is a plan to make this available What will be shared: When we publish article in journal When: After the article is published To whom: Researchers working in academic and scientific institutions Conditions: If there are additional questions Where to obtain: Person responsible for the accountability of Dr. Alireza Kamali alikamaliir@yahoo.com How to obtain: Send an e-mail containing the layout specifications to the person responsible for the scientific answer Comments:
public Alireza Kamali
Shahid Shirodi street, Valiasr square, Valiasr hospital
Arak Iran (Islamic Republic of) 3819691187 +98 86 3313 4715 alikamaliir@yahoo.com Arak University of Medical Sciences scientific Alireza Kamali
Shahid Shirodi street, Valiasr square, Valiasr hospital
Arak Iran (Islamic Republic of) 3819691187 +98 86 3313 4715 alikamaliir@yahoo.com Arak University of Medical Sciences Iran (Islamic Republic of) All patients with rhinoplasty referring to Amir Kabir Hospital in Arak Patients aged 18 to 50 years Patients with ASA class I and II All patients undergo surgery by a surgeon Operating time is between 90 to 180 minutes 18 years 50 years Both Patients outside the age range of 18 to 50 years Patients with ASA classes 3 and 4 Patients who have allergies to Dexmedetomidine or Remifentanil Treatment - Drugs Treatment - Drugs Intervention group 1: Dexmedetomidine, 0.5 micro grams per kilogram per hour for infusion during surgery Intervention group 2: Remifentanil 50 to100 micro grams per kilogram per hour for infusion during surgery Mean arterial pressure. Timepoint: At 15, 30, 45, 60, 90, and 120 minutes after the start of operation. Method of measurement: Barometer. Mean of pulse rate. Timepoint: At 15, 30, 45, 60, 90, and 120 minutes after the start of operation. Method of measurement: Pulse rate counts. Mean of recovery time. Timepoint: Recovery. Method of measurement: Record time in recovery book. Mean of bleeding score. Timepoint: At 15, 30, 45, 60, 90, and 120 minutes after the start of operation. Method of measurement: Suction and observation of blood gas. Arak University of Medical Sciences Approved 2018-08-19 Ethics committee of Arak University of Medical Sciences Ethics comittee, Research center, Payambar Azam complex, Basij Squre ,Sardasht,Arak Arak Markazi Iran (Islamic Republic of)