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IRCT20190405043168N1 IRCT 2019-09-06 Mashhad University of Medical Sciences The Effect of conventional antiglaucoma medications; such as Timolol, Brimonidin, Latanoprost and Dorzolamide Eye Drops on Prepapillary and Optic Nerve Head Circulation The Effect of conventional antiglaucoma medications; such as Timolol, Brimonidin, Latanoprost and Dorzolamide Eye Drops on Prepapillary and Optic Nerve Head Circulation 2019-08-23 anticipated 80 Complete https://irct.ir/trial/38651 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Health service research, Randomization description: In this study, volunteer healthy volunteers were randomly assigned to one of the four intervention groups. For each group, one of four topical timolol drugs, dorzolamid drops, topical bimonidine drops, and topical latannoprost drops were used in the right eye, Blinding description: The four drugs used by one of the physicians are initially called abbreviated, and thus the patient, the perimeter papillary permeate optometry and measurement gauge, and the statistic consultant who has the purpose of analyzing the data, are unaware of the type of drops. After the data analysis is completed, the nature of the drug groups is determined. Bioequivalence Evaluation of the effect of anti-glaucoma drugs on the blood flow of the optic nerve head. Intervention 1: Intervention group: right eye of volunteers randomly assigned to one of antiglaucoma drugs. Intervention 2: Control group: artificial tear instilled in the left eye of participants. Yes - There is a plan to make this available What will be shared: All of data would be accessible When: 6 month after publish of results To whom: Researchers in academic institutes Conditions: there would no restrictions Where to obtain: Khatam Al-Anbia Hospital – Gharani ave - Dr. ghannad How to obtain: official request should send to khatam al anbia hospital Comments:
public saeed shokoohi rad
Gharani ave , Khatam Al-Anbia hospital
Mashhad Iran (Islamic Republic of) 9195965919 +98 51 3728 1401 shokoohirads@mums.ac.ir Mashhad University of Medical Sciences scientific marzieh ghannad
Khatam Al-Anbia Hospital – Gharani ave
Mashhad Iran (Islamic Republic of) 9195965919 +98 51 3728 1401 anaghannad@gmail.com Mashhad University of Medical Sciences Iran (Islamic Republic of) Conscious Consciousness Normal Ocular Examination Normal IOP 20 years 40 years Both Diabetes and hypertension and family history of high pressure of the eye History of ocular disease Allergy to antiglaucoma medications Pregnancy and breastfeeding Treatment - Drugs Placebo Intervention group: right eye of volunteers randomly assigned to one of antiglaucoma drugs Control group: artificial tear instilled in the left eye of participants Evaluation of the effect of anti-glaucoma drugs on the blood flow of the optic nerve head. Timepoint: Before taking the medication and at the time of the peak of the medication. Method of measurement: OCTA optivue Device. Mashhad University of Medical Sciences Approved 1397-09-13 The Ethics Committee of Mashhad University of Medical Sciences Azadi Square, University of Pardis, Faculty of Medicine, Mashhad, Iran Mashhad Razavi Khorasan Iran (Islamic Republic of)