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IRCT20190323043102N1 IRCT 2020-03-14 Artesh University of Medical Sciences Effect of nano silver particles on pain control between root canal therapy sessions in premolar teeth Comparison of the effect of intracanal drugs on calcium hydroxide blend with nano silver particles and calcium hydroxide blend and normal saline on pain relief between root canal therapy in patients with symptomatic apical periodontitis 2019-07-01 anticipated 30 Complete https://irct.ir/trial/38636 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Other design features: Silver nano particles are a new material in dentistry and most of the studies on this material are about its antibacterial properties. Microorganisms are the main cause of pain between root canal treatment sessions with apical periodontitis. So we decided to design a study about the relation of the pain between root canal therapy sessions and nano silver particles, Randomization description: The patients were categorized by an assistant using random numbers table, Blinding description: number 1 was assigned to calcium hydroxide with nano silver particles , number 2 was assigned to calcium hydroxide , number 3 was assigned to sterile dry cotton pellet. Then, on behalf of the intracanal drug type, 10 numbers of each intracanal medication were written on identical so that the numbers could not be identified. The papers were poured into a box and we asked the ward assistant to remove one sheet of paper for each patient and enter it into the file. The patient and data analyzer were unaware of the root canal drug type and after data collection, the number assigned to each intracanal medication was reported to the data analyzer instead of the type of intracanal medication. 1-2 Pain between root canal treatment sessions. Intervention 1: Intervention group 1: In patient's premolar teeth with symptomatic apical periodontitis, calcium hydroxide with silver nano particles was used as intracanal medication one time between root canal therapy sessions at the end of the first treatment session after cleaning and shaping of root canal system for 4 days. Intervention 2: Intervention group 2: In patient's premolar teeth with symptomatic apical periodontitis, calcium hydroxide with normal saline was used as intracanal medication one time between root canal therapy sessions at the end of the first treatment session after cleaning and shaping of root canal system for 4 days. Intervention 3: Control group: In patient's premolar teeth with symptomatic apical periodontitis, sterile dry cotton pellet was used as placebo medication one time between root canal therapy sessions at the end of the first treatment session after cleaning and shaping of root canal system for 4 days. Yes - There is a plan to make this available What will be shared: Patient record, file summary, visual analogue scale (VAS) form, and 5 periapical graphs of patients are available which can be published if necessary after deleting patients' names and telephone numbers. When: Start of access period 6 months after printing results To whom: Researchers working in academic and scientific institutions Conditions: Those who are researching silver nanoparticles Comparison of pain levels between sessions in the upper and lower jaw Comparison of pain between sessions between men and women Where to obtain: mmortezaei7777@gmail.com Department of Endodontics, Faculty of Dentistry, Army University of Medical Sciences How to obtain: The reason for the data request should be verified by the endodontic department. Comments:
public Mohsen Mortezaei
No.27 ,Etemadzade sreet, West Fatem street
Tehran Iran (Islamic Republic of) 1411718541 0098216-86096350 mmortezaei7777@gmail.com Artesh University of Medical Sciences scientific Majid Ajami
Faculty of Dentistry, Artesh University of Medical Sciences, East Alley St., Adjouani Ave.
Tehran Iran (Islamic Republic of) 1234567890 0098 21 228998983 dr_ajami2@yahoo.com Artesh University of Medical Sciences Iran (Islamic Republic of) Patient seeking root canal treatment closed apex no limit no limit Both Systemic disease tooth with internal or external resorption Use of antibiotics and analgesics before treatment pregnancy Non-repairable teeth A history of chronic use of analgesics, narcotic or alcohol K04.4 Acute apical periodontitis of pulpal origin Prevention Prevention Placebo Intervention group 1: In patient's premolar teeth with symptomatic apical periodontitis, calcium hydroxide with silver nano particles was used as intracanal medication one time between root canal therapy sessions at the end of the first treatment session after cleaning and shaping of root canal system for 4 days. Intervention group 2: In patient's premolar teeth with symptomatic apical periodontitis, calcium hydroxide with normal saline was used as intracanal medication one time between root canal therapy sessions at the end of the first treatment session after cleaning and shaping of root canal system for 4 days. Control group: In patient's premolar teeth with symptomatic apical periodontitis, sterile dry cotton pellet was used as placebo medication one time between root canal therapy sessions at the end of the first treatment session after cleaning and shaping of root canal system for 4 days. Post-treatment pain above 3. Timepoint: between two root canal sessions at 6, 12 , 24 and 48 hours after first session (2 session root canal with intracanal medication ). Method of measurement: Visual analog scale (VAS): patients are asked to mark the pain level at 6, 12 , 24 and 48 hours after first session of their treatment then the 10 cm line of each period was measured from left(no pain) in millimeter. Artesh University of Medical Sciences Approved 2019-01-28 Ethics Committee of AJA University of Medical Sciences AJA University of Medical Sciences, Etemadzade avenue., West Fatemi boulevard, Tehran Tehran Tehran Iran (Islamic Republic of)