IRCT20131228015968N5 IRCT 2019-05-03 Vice chancellor for research, Shahid Beheshti University of Medical sciences- School of Nutrition The effect of probiotic supplementation on obesity Effect of Probiotic Supplementation on Anthropometric, Body composition, Appetite, Eating Behavior, plasma level of Leptin , Neuropeptide Y and Oxytocin in Obese Women with Food addiction 2019-01-05 anticipated 60 Complete https://irct.ir/trial/38557 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, participants were classified into two groups with obesity grade A (30-34.9) and obesity grade 2 (34.9-39.9) by stratified blocked randomization method and based on BMI and randomly assigned to One of the groups receiving the supplement is a probiotic or placebo group. Separate randomization is done within each group. The size of the blocks is 4, with two assignments to the intervention group (A) and two allocations to the placebo group (B). There are 6 different permutations of AABB, ABAB, BBAA, BABA, ABBA, BAAB, Blinding description: Prior to the beginning of the study, the canisters containing the capsules are coded by individuals other than the research team, A and B, so that the knowledge of the type of capsules received by each group is not known to the researcher. Since this study is double blind, the subjects , the researchers have no information about the individuals located in the studied and control groups. 3 Obesity. Intervention 1: Intervention group received daily two probiotic capsules containing (Lactobacillus acidophilus, Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium langum, Lactobacillus rhominosus and Lactobacillus rotiria (every 12 hours) with microbial load 2* 10^9 for 12 weeks manufactured in Tak Gene, Iran. Intervention 2: Control group: received daily two placebo capsules containing 300 mg of starch every 12 hours for 12 weeks. manufactured in Zahravi Pharmaceutical Company. The placebo is completely similar to the probiotic supplement in terms of its appearance. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this available