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IRCT20190307042963N1 IRCT 2019-04-14 Shiraz University of Medical Sciences Analysis of treatment with quetiapin in bipolar patients with obsessional symptom Quetiapine versus placebo in the treatment of obsession symptoms in bipolar patients wih lithium +benzodiazepin medication,A double blind randomized controlled clinical trial 2019-05-22 anticipated 40 Complete https://irct.ir/trial/38187 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: They were divided randomly in basis of block permutation into two groups of intervention and control, Blinding description: The patients divided into two groups according to table of randome number.one group give quetiapin and another one give pelacebo. The patients and supervisor physician do not know about kinds of group. 3 Condition 1: Bipolar disorders. Condition 2: Obsessive compulsive disorder. Intervention 1: Intervention group: 20 patient give quetiapin with lithium and benzodiazepin, start with 25 mg twice daily and increase 50 mg weekly until 200 mg daily. Intervention 2: Control group: 20 patient give pelacebo with lithium and benzodiazepin. Yes - There is a plan to make this available What will be shared: Yale brown scal, young mania questionnaire and hamilton questionnaire of patients- Analysis of data in spss When: starting 6 months after publication To whom: this only available for people working in academic institutions Conditions: We can give data to academic institutions by email and they can use our data with mention refrence Where to obtain: By email:bahareh.ghahramanpouri@gmail.com How to obtain: About 1 month after recive message we send data Comments:
public Bahareh Ghahramanpouri
Chamran Blvd, Hafez Hospital
Shiraz Iran (Islamic Republic of) 7194634786 +98 71 3647 9531 Bahareh.ghahramanpouri@gmail.com Shiraz University of Medical Sciences scientific Bahareh Ghahramanpouri
Chamran Blvd, Hafez hospital
Shiraz Iran (Islamic Republic of) 7194634786 +98 71 3647 9531 Bahareh.ghahramanpouri@gmail.com Shiraz University of Medical Sciences Iran (Islamic Republic of) The patients with impression of bipolare disorder according to dsm v The patients have score of more than 16 in yale brown score The patients have score of equal or lesser than 17 in Young mania questionnaire The patients have score of equal or lesser than 7 in Hamilton depression questionnaire no limit no limit Both The patients in acute phase of depression or mania The patients with cardiac, respiratory, renal or GI disorder Pregnant patients F06.34 F42 Mood disorder due to known physiological condition with mixed features Obsessive-compulsive disorder Treatment - Drugs Placebo Intervention group: 20 patient give quetiapin with lithium and benzodiazepin, start with 25 mg twice daily and increase 50 mg weekly until 200 mg daily Control group: 20 patient give pelacebo with lithium and benzodiazepin Evaluate severity of obsession in bipolar patients. Timepoint: Before intervention and 4,8 and 8 weeks after intervention. Method of measurement: Yale brown scale. Shiraz University of Medical Sciences Approved 2019-04-07 Ethics committee of shiraz university medical sciencs Zand street, medical science university Shiraz Fars Iran (Islamic Republic of)