IRCT20081208001497N8 IRCT 2019-05-07 Esfahan University of Medical Sciences Effect of Melatonin in brain injury Evaluation of the effect of melatonin on biomarkers of mitochondrial damage in patients with brain injury hospitalized in Alzahra hospital, Isfahan: A randomized placebo-controlled clinical trial 2019-04-21 anticipated 60 Complete https://irct.ir/trial/38043 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: After the preparation of Melatonin and its placebo, each packet is assigned a code using the random number table, and the two codes are allocated to the drug and the placebo. Block randomization will performed in random blocks of four. At the end of the study, the code of each patient is decoded and the type of drug is determined, Blinding description: Patient and the researcher who measuring the study outcomes are blind to the distribution of patients in the melatonin and placebo groups until the completion of the study and the detection of its codes. 3 Brain injury. Intervention 1: Intervention group: Patients in drug group will be received Melatonin tablet (Razak Pharmaceutical company, Tehran, Iran), 20 mg daily for 5 days. Intervention 2: Control group: Patients in control group will be received Melatonin tablet (Prepared in pharmacy faculty), 20 mg daily for 5. No - There is not a plan to make this available Justification or reason for not sharing IPD is confidential