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IRCT20190228042870N1 IRCT 2019-04-17 Kerman University of Medical Sciences Evaluation the effect of endurance training and MitoQ supplementation on blood pressure Evaluation the effect of four weeks endurance training and MitoQ supplementation alone and in combination on serum level of some of microRNAs effective on blood pressure and oxidant, antioxidant, inflammatory and on functional cardiac factors in hypertensive patients 2019-04-21 anticipated 60 Complete https://irct.ir/trial/37904 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, participants randomly and on the basis of throwing dice into separate groups to compare different treatments by researchers, Blinding description: The patients and all study personnel were blinded to treatment assignment and lipid measurements. Treatments that take place on the participants are impartial and it is not clear which treatment is the best when it comes to clinical testing. N/A Hypertension. Intervention 1: Control group: Hypertension: People in this study have a systolic blood pressure equal to or greater than 140 mm Hg and a diastolic blood pressure equal to or greater than 90 mm Hg. During the study period, which lasted for 4 weeks, no intervention was performed on They do not accept. Intervention 2: Intervention group: 1); Hypertension group with endurance training: In this group, people with hypertension for 4 weeks (3 times a week), exercise endurance bike with specified strength and depending on the aerobic capacity. Intervention 3: Intervention group: 2) Hypertension group with MitoQ supplemented oral administration: In this group, people with hypertension receive a supplement of oral MitoQ capsules at a dose of 20 mg/day for 4 weeks a day. MitoQ is a mitochondria-targeted antioxidant(Advanced CoQ10 Formula). MitoQ is produced by MitoQ company (Auckland, New Zealand). Intervention 4: Intervention group: 3) Hypertension group with oral administration of placebo: In this group, people with hypertension receive a placebo capsule of MitoQ daily for 4 weeks a day. Intervention 5: Intervention group: 4) Hypertension group with MitoQ supplement supplementation and endurance training: In this group, people with hypertension have a cycling endurance training for 4 weeks in 3 times per week, and at the same time they receive a daily MitoQ capsule of 20 mg per day. MitoQ is a mitochondria-targeted antioxidant(Advanced CoQ10 Formula). MitoQ is produced by MitoQ company (Auckland, New Zealand). Intervention 6: Intervention group: 5) The group was in hypertension with oral administration of placebo (placebo) and endurance training: In this group, people with hypertension have a cycling endurance training for 4 weeks in 3 times per week, and they receive a single placebo capsule of MitoQ daily for oral administration. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Continue the research
public Yaser Masoumi-Ardakani
Physiology Research Center, Deputy of Research and Technology of Kerman University of Medical Sciences, Jahad Blvd, Ebne Sina Street
kerman Iran (Islamic Republic of) 7619813159 +98 34 3223 6839 ymab125@gmail.com Kerman University of Medical Sciences scientific Yaser Masoumi-Ardakani
Physiology Research Center, Deputy of Research and Technology of Kerman University of Medical Sciences, Jahad Blvd, Ebne Sina Street
kerman Iran (Islamic Republic of) 7619813159 +98 34 3223 6839 ymab125@gmail.com Kerman University of Medical Sciences Iran (Islamic Republic of) systolic blood pressure > 140 mmHg Diastolic pressure > 90 mmHg 40 years 55 years Male Liver, kidney, lung, diabetes diseases and certain diseases like cancer 110-115 Hypertensive diseases Diagnosis Rehabilitation Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Control group: Hypertension: People in this study have a systolic blood pressure equal to or greater than 140 mm Hg and a diastolic blood pressure equal to or greater than 90 mm Hg. During the study period, which lasted for 4 weeks, no intervention was performed on They do not accept. Intervention group: 1); Hypertension group with endurance training: In this group, people with hypertension for 4 weeks (3 times a week), exercise endurance bike with specified strength and depending on the aerobic capacity. Intervention group: 2) Hypertension group with MitoQ supplemented oral administration: In this group, people with hypertension receive a supplement of oral MitoQ capsules at a dose of 20 mg/day for 4 weeks a day. MitoQ is a mitochondria-targeted antioxidant(Advanced CoQ10 Formula). MitoQ is produced by MitoQ company (Auckland, New Zealand). Intervention group: 3) Hypertension group with oral administration of placebo: In this group, people with hypertension receive a placebo capsule of MitoQ daily for 4 weeks a day. Intervention group: 4) Hypertension group with MitoQ supplement supplementation and endurance training: In this group, people with hypertension have a cycling endurance training for 4 weeks in 3 times per week, and at the same time they receive a daily MitoQ capsule of 20 mg per day. MitoQ is a mitochondria-targeted antioxidant(Advanced CoQ10 Formula). MitoQ is produced by MitoQ company (Auckland, New Zealand). Intervention group: 5) The group was in hypertension with oral administration of placebo (placebo) and endurance training: In this group, people with hypertension have a cycling endurance training for 4 weeks in 3 times per week, and they receive a single placebo capsule of MitoQ daily for oral administration. MiR-21. Timepoint: At the beginning of the study (before the intervention) and 28 days after taking the MitoQ supplement or performing endurance training. Method of measurement: Real-Time PCR. MiR-27a. Timepoint: At the beginning of the study (before the intervention) and 28 days after taking the MitoQ supplement or performing endurance training. Method of measurement: Real-Time PCR. MiR-126. Timepoint: At the beginning of the study (before the intervention) and 28 days after taking the MitoQ supplement or performing endurance training. Method of measurement: Real-Time PCR. MiR-222. Timepoint: At the beginning of the study (before the intervention) and 28 days after taking the MitoQ supplement or performing endurance training. Method of measurement: Real-Time PCR. Blood pressure. Timepoint: before the intervention and Days 1, 3, 5, ... and 28th day. Method of measurement: Sphygmomanometer. Percentage of arterial oxygen saturation. Timepoint: Before training, during training, immediately after training and at intervals of 15, 30 and 45 minutes after training. Method of measurement: Pulse Oximeter. HDL-c. Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer. Oxidized LDL. Timepoint: before the intervention and 28th day. Method of measurement: Elisa kit. Cholestrol. Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer. Triglyceride. Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer. Heart rate. Timepoint: Before training, during training, immediately after training and at intervals of 15, 30 and 45 minutes after training. Method of measurement: Pulse Oximeter. Left Ventricular End-Systolic Diamater. Timepoint: before the intervention and 28th day. Method of measurement: Echocardiography. Left Ventricular End-diastolic Diamater. Timepoint: before the intervention and 28th day. Method of measurement: Echocardiography. Ejection Fraction. Timepoint: before the intervention and 28th day. Method of measurement: Echocardiography. Shortening Fraction. Timepoint: before the intervention and 28th day. Method of measurement: Echocardiography. Superoxide dismutase. Timepoint: before the intervention and 28th day. Method of measurement: Elisa kit. Glutathione Peroxidase. Timepoint: before the intervention and 28th day. Method of measurement: Elisa kit. Malondialdehyde. Timepoint: before the intervention and 28th day. Method of measurement: Elisa kit. Interleukin-6. Timepoint: before the intervention and 28th day. Method of measurement: Elisa kit. Hs-CRP. Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer. Creatinine. Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer. Alanine aminotransferase (SGPT). Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer. Aspartate aminotransferase (SGOT). Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer. Alkaline Phosphatase. Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer. Kerman University of Medical Sciences Approved 2019-03-17 Research Ethics Committee of Kerman University of Medical Sciences Jihad Bolvd.Ebnsina Ave.Kerman,Iran kerman Kerman Iran (Islamic Republic of)