IRCT201311103690N4 IRCT 2014-01-20 Vice chancellor for research, Tabriz University of Medical Sciences Effects of minocycline and emdogain in the treatment of peri-implant mucosal inflammation Comparison the microbiological effects of sustain released microspherical minocycline and emdogain in the non-surgical treatment of peri-implant mucosal inflammation 2013-08-27 anticipated 20 Complete https://irct.ir/trial/3785 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Patients will be randomly assigned to receive one of treatment protocols. The allocation sequence will be concealed from the examiner, patients and statistical analyzers. Staff members who obtain the results will not be aware how the study groups are assigned. Moreover the intervention staff, who delivered the intervention will not also be given the results. Therefore, the final results will not be revealed to any of the investigators, staff, or participants. 2 mocusal inflammation around dental implants. Intervention 1: Control: Instruction of oral hygiene and debridement of subgingival environment using ultrasonic scaler and glycine-based powder air polishing. Intervention 2: Intervention 1 : Two weeks after mechanical debridement, one mg of minocycline hydrochloride microspheres (Arestin OraPharma, Inc USA) will be located subgingivally in the affected sites around the implant. Intervention 3: Intervention 2 : Two weeks after mechanical debridement, 0.1 ml of Enamel Matrix Derivative Gel (Emdogain) 0.3 ml straumann will be located subgingivally in the affected sites around the implant with the help of syringe.