IRCT20190226042854N1 IRCT 2019-03-17 Zanjan University of Medical Sciences The effect of arthromac plus in the treatment of knee arthritis Evaluating and comparing the efficacy of treatment with chondroitin sulfate and hyaluronic acid in patients with knee osteoarthritis 2018-04-21 anticipated 54 Complete https://irct.ir/trial/37828 interventional Randomization: N/A, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: A complete explanation was given to the patient about studying and comparing the therapeutic effect of drugs. The patient then received both ampoule arthromac plus (hyaluronic acid-chondrotin sulfate) and arthromac (hyaluronic acid). Then arthromac Plus was injected in the right knee and arthromac in the left knee. The patient did not have any information about the type of injectable drug in his knees. The appearance of both ampoules was identical (milky). During the study, only a physician was aware of the type of injected drug on the knees and information was collected by the same physician. The other person, including the patient himself and the nurse and the medical staff, did not know the type of injected drug on the knees. 2-3 Osteoarthritis. Intervention 1: Intervention group: Patient right knee; In this group injections of intravenous injection of Arthromc plus, containing 3 ml of hyaluronic acid-chondrocyte sulfate, at a concentration of 20 MG / ML, made in France, NOVATEX BIOENGINEERING. Intervention 2: Control group: The left knee was injected intradermally. In this group, the injection of intravenous injection of artrocomic ampoule containing 3 ml of hyaluronic acid at a concentration of 20 MG / ml, made in France, NOVATEX BIOENGINEERING. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information