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IRCT20160422027520N11 IRCT 2019-03-07 Tabriz University of Medical Sciences Treatment of elderly patients with ischemic stroke Effects of Anti-CD20 monoclonal antibody on immunologic factors in elderly patients with ischemic stroke 2019-05-20 anticipated 12 Complete https://irct.ir/trial/37725 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Elderly patients with ischemic stroke. Intervention 1: Intervention group: Elderly patients with ischemic stroke who received the anti-CD20 monoclonal antibody. Intervention 2: Control group: Elderly people with ischemic stroke are not receiving the anti-CD20 monoclonal antibody. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Mehdi Yousefi
Tabriz University of Medical Sciences, Golgasht Avenue, Tabriz
Tabriz Iran (Islamic Republic of) 5166616471 +98 41 3336 4665 Yousefime@tbzmed.ac.ir Tabriz University of Medical Sciences scientific Mehdi Yousefi
Tabriz University of Medical Sciences, Golgasht Avenue,Tabriz, Iran
Tabriz Iran (Islamic Republic of) 5166616471 +98 41 3336 4665 yousefime@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Willingness to cooperate Aged 60 to 75 years Diagnosis of ischemic stroke by a neurologist Radiological findings (MRI, CT) consistent with clinical diagnosis of ischemic stroke NIHSS score between 6 and 22 60 years 75 years Both Use of nutritional supplements and antioxidant and alpha-lipoic acid during a month before the study History of diabetes, high or low blood pressure and other chronic diseases (kidney, lung disorders, etc.), anemia, thrombocytopenia A history of autoimmune diseases, immunodeficiency diseases, asthma and allergies Cancer Viral infections (hepatitis B, influenza ...) Occurrence of recurrence of disease during the study Evidence from CT or MRI based on acute or chronic intracerebral hemorrhage, arteriovenous malformation (AVM), Subarachnoid hemorrhage (SAH) brain aneurysm or tumor. Symptoms or signs of neurology that quickly recover during screening and are likely to recover completely within 24 hours. Not wanting to continue cooperation I63.9 Ischemic Stroke Treatment - Drugs Treatment - Drugs Intervention group: Elderly patients with ischemic stroke who received the anti-CD20 monoclonal antibody Control group: Elderly people with ischemic stroke are not receiving the anti-CD20 monoclonal antibody Determination of Frequency of CD20 + B Cells in Elderly People with Ischemic Stroke in the Group Receiving Anti-CD20 Antibody and Control Group. Timepoint: After 24 hours of stroke in acute phase. Method of measurement: Flow cytometry. Determination of the frequency of Th1 and Th17 cells in the elderly with ischemic stroke in the group receiving Anti-CD20 Antibody and Control Group. Timepoint: After 24 hours of stroke in acute phase. Method of measurement: Flow cytometry. Determination of the expression of gene expression of effective transcription factors in the development of Th1 and Th17 cells in the elderly with ischemic stroke in the group receiving Anti-CD20 Antibody and Control Group. Timepoint: After 24 hours of stroke in acute phase. Method of measurement: Quantitative Real time PCR. Determination of the expression of cytokine genes from Th1 and Th17 cells in the elderly with ischemic stroke in the group receiving Anti-CD20 Antibody and Control Group. Timepoint: After 24 hours of stroke in acute phase. Method of measurement: Quantitative Real time PCR. Determination of the secretion of cytokines secreted from Th1 and Th17 cells in the elderly with ischemic stroke in the group receiving Anti-CD20 Antibody and Control Group. Timepoint: After 24 hours of stroke in acute phase. Method of measurement: Quantitative Real time PCR. Determination of infarction brain tissue in elderly patients with ischemic stroke in the group receiving monoclonal antibodies anti-antigen CD20 and control group. Timepoint: One month after receiving the drug. Method of measurement: MRIĜŒCT scan. Tabriz University of Medical Sciences Approved 2018-12-03 Ethics committee of Tabriz University of Medical Sciences Tabriz University of Medical Sciences , Daneshghah st, Tabriz, Tabriz East Azarbaijan Iran (Islamic Republic of)