IRCT20160711028878N2 IRCT 2020-02-01 Isfahan Research Department of Medical Sciences Effect of a mixture of doxycycline and venlafaxine on the healing of diabetic foot ulcers Therapeutic potential of loaded doxycycline and Venlafaxine on nanofiber scaffolds for wound healing in diabetic foot 2015-10-02 anticipated 20 Complete https://irct.ir/trial/37678 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: This study was a simple randomization study where 1 to 40 were written on a sheet and placed in a box in a manner that was unclear. One sheet was taken for each patient. Even numbers were assigned as the treatment group and odd numbers as the control group. 2-3 Treatment of diabetic foot ulcer. Intervention 1: Intervention group: Nanofibers containing doxycycline and venlafaxine were prepared from Nano Novin Polymer Factory (NATO MAND), then FTIR test was used to determine drug quantity and release rate. Their mechanical strength was then tested with a Tensile device. The morphology of the samples was analyzed by electron microscopy (TEM). The patients' foot ulcers were washed with serum and the nano-fiber scaffolds were placed on their wounds every other day, with treatment continued for one week to 20 days. Finally, the skin permeability of the drugs to nanofibers was tested on the hairless abdominal skin of the rat. The results were measured for a total duration of 12 weeks with a spectrophotometer. Intervention 2: Control group: This group had their normal treatment and scaffold dressing was not used to them. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is a need for further coordination with the center for dissemination