IRCT20090609002017N33 IRCT 2019-04-06 Nutrition Research Center, Tabriz University of Medical Science Effect of sodium butyrate in prevention and treatment of type 2 diabetes The effect of sodium butyrate supplementation on serum oxidative stress indices and gene expression level of pyroptosis related inflammatory factors in type 2 diabetic patients: A randomized, double-blind, placebo-controlled trial 2019-03-25 anticipated 42 Complete https://irct.ir/trial/37654 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Samples will be assigned to intervention and control groups by random blocking, Blinding description: In this study, investigator and participants will be unaware of the type of supplementation (sodium butyrate or placebo).The person responsible for the preparation of capsules' packs (a person completely unrelated to the study) will be asked to assign a code to each of the two packages (sodium butyrate and placebo), and to keep the codes up to the end of the study and data analysis. 3 Diabetes mellitus Type 2. Intervention 1: Group 1 will receive sodium butyrate capsules (BodyBio) for 6 weeks at a daily dose of 600 mg in the form of capsules of 100 mg with meals. Intervention 2: Control group: Group 2 will use starch capsule as placebo for 6 weeks at a daily dose of 6 capsule with meals. Yes - There is a plan to make this available What will be shared: Individual participant data that underlie the outcomes reported in this article, after deidentification (text, tables, figures, and appendices),Study Protocol, Statistical Analysis Plan, Clinical Study Report When: Beginning 6 months and ending 2 years following article publication To whom: Researchers who provide a methodologically sound proposal. Conditions: The datasets are available from the corresponding author on reasonable request and to achieve aims in the approved proposal. Where to obtain: Proposals should be directed to corresponding author. How to obtain: All data requests should be submitted to the corresponding author for consideration. To gain access, data requestors will need to sign a data access agreement. Comments: