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IRCT20171122037593N1 IRCT 2019-03-13 Tehran University of Medical Sciences Using melatonin pill to reduce the risk of cancer due to exposure to radiation doses from CT imaging . The investigation radioprotective effect against DNA double-stranded breaks induced in Peripheral blood lymphocytes of patients undergoing CT examinations of the abdomenpelvic of melatonin by immunofluorescence assay 2019-03-10 anticipated 30 Complete https://irct.ir/trial/37383 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients will be provided with a computer-generated randomization list by a statistical consultant, and an out-of-site person who does not know about the study will give patients with melatonin and placebo on the list, Blinding description: Patients will be provided with a computer-generated randomization list by a statistical consultant, and an out-of-site person who does not know about the study will give patients with melatonin and placebo on the list. The collection of blood samples and preparation of lam will be done by the main investigator, but the coded lam will be given to read the DNA damage to a specialist who does not know these codes and groupings (as compared to the blind slamming code). 3 .... Intervention 1: Control group: Patients will be administered only radiation from CT scan and no additional procedures will be done. Intervention 2: Intervention group: This group will be administered two 50 mg tablets of melatonin 1 hour before imaging, before exposure to radiation from CT scans. Yes - There is a plan to make this available What will be shared: Only age and gender will be available to everyone. When: From 2019. To whom: Just researcher at universities Conditions: There are no specific data other than age. Where to obtain: Refer to Mr Eskandari How to obtain: After an email, some can have the age of people and gender Comments: Due to the fact that patients are not given specific information other than age and written informed consent, there is no need to publish specific information.
public DR Ali Reza Shirazi
Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Sina Campus - Tehran University of Medical Sciences
Tehran Iran (Islamic Republic of) 1417613151 +98 21 6648 2654 shirazia@sina.tums.ac.ir Tehran University of Medical Sciences scientific Dr. Ali Reza Sirazi
Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Sina Campus - Tehran University of Medical Sciences
tehran Iran (Islamic Republic of) 1417613151 +98 21 6648 2654 shirazia@sina.tums.ac.ir Ahvaz University of Medical Sciences Iran (Islamic Republic of) healthy person non-athlete non-smoker non-alcoholic no-radiation therapy no- history of chemotherapy 25 years 60 years Both smoker alcoholic having radiation therapy having chemotherapy . . N/A Prevention Control group: Patients will be administered only radiation from CT scan and no additional procedures will be done. Intervention group: This group will be administered two 50 mg tablets of melatonin 1 hour before imaging, before exposure to radiation from CT scans. Gamma-h2ax foci per cell that represent double strand break( DSB) in cell. Timepoint: Counting the number of DSB in the control group at zero time without taking melatonin and also 1 hour before radiation. Method of measurement: Using the immune fluorescence assay, using gamma-h2ax antibodies and fluorescence microscopy, the number of gamma-h2ax foci is counted. Tehran University of Medical Sciences Approved 2018-05-15 Ethics Committee of Tehran University of Medical Sciences, Tehran, Iran. Building no.1, Northern gate of the University, Poursina St. Qods St. Enqelab St.Tehran. Tehran Tehran Iran (Islamic Republic of)