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IRCT20190121042444N1 IRCT 2019-06-13 Shahid Beheshti University of Medical Sciences Evaluating the Effect of Dexmedetomidine Infusion on Gene Expression of Inflammatory Cytokines & Lymphocyte T CD4 + Transcription Factors in Elective Abdominal Aortic Aneurysm Repair - Evaluating the Effect of Dexmedetomidine Infusion on Gene Expression of Inflammatory Cytokines & Lymphocyte T CD4 + Transcription Factors in Elective Abdominal Aortic Aneurysm Repair 2018-07-23 anticipated 30 Complete https://irct.ir/trial/36997 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: -, Randomization description: Based on random numbers, the patient and the individual who fill the table are unaware, Blinding description: The patient and anesthetist who fill the table are unaware of the study. 3 Abdominal Aortic Aneurysm. Intervention 1: The intervention group was subjected to anxiolytic infusion with doses of 0.3 mg / kg / hour doses of DEX until aortic clamp. Patients' blood samples were taken to determine the level of inflammatory cytokines and the level of expression of inflammatory mRNAs in the preoperative period, after induction of anesthesia, 24 hours after surgery, 4 days after surgery, and at discharge time, from a patient's peripheral blood sample size And the effect of DEX on them will be investigated. Intervention 2: Control group: There are no interventions in this group. Yes - There is a plan to make this available What will be shared: A portion of the information, such as information on the main outcome or the like, can be shared When: 1399 To whom: Researchers working in academia and academia Conditions: Analyzes on the delivered data are allowed Where to obtain: Shohada Tajrish Hospital Department of Anesthesiology - Maidan Tajrish Building No. 1 Second Floor Operation Room Dr. Behnaz Telephone 22741174 Shohada Tajrish Hospital - Tajrish Square Building No. 1 Second Floor Ms. َ Arinnia Telephone 22718002 Internal 310 How to obtain: Apply for one month Comments:
public faranak behnaz
tajrish Sq;shohada hospital
tehran Iran (Islamic Republic of) 1989934148 +98 21 2274 1174 faranak.behnaz@gmail.com Shahid Beheshti University of Medical Sciences scientific faranak behnaz
tajrish Sq;shohada hospital
tehran Iran (Islamic Republic of) 1989934148 +98 21 2274 1174 faranak.behnaz@gmail.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Patients with abdominal aortic aneurysms referring to Shohadaye Tajrish Hospital who are candidates for elective aneurysm repair surgery will be included in the study. no limit no limit Both Previous history of aortic surgery ASA Class III and above IBD Malignancies Chronic inflammatory diseases Taking corticosteroids Emergency surgery Any unstable patient during surgery Any addiction - - Diagnosis Diagnosis The intervention group was subjected to anxiolytic infusion with doses of 0.3 mg / kg / hour doses of DEX until aortic clamp. Patients' blood samples were taken to determine the level of inflammatory cytokines and the level of expression of inflammatory mRNAs in the preoperative period, after induction of anesthesia, 24 hours after surgery, 4 days after surgery, and at discharge time, from a patient's peripheral blood sample size And the effect of DEX on them will be investigated. Control group: There are no interventions in this group. Relative level of mRNA; IL6. Timepoint: Before the beginning of the intervention (beginning of the study), the first day and the third day, and the time of discharge. Method of measurement: Sampling from patient's blood and filling in the questionnaire. Relative level of mRNA; TNF-α. Timepoint: Before the beginning of the intervention (beginning of the study), the first day and the third day, and the time of discharge. Method of measurement: Sampling from patient's blood and filling in the questionnaire. Relative level of Foxp3 mRNA. Timepoint: Before the beginning of the intervention (beginning of the study), the first day and the third day, and the time of discharge. Method of measurement: Sampling from patient's blood and filling in the questionnaire. Relative level of GATA3mRNA. Timepoint: Before the beginning of the intervention (beginning of the study), the first day and the third day, and the time of discharge. Method of measurement: Sampling from patient's blood and filling in the questionnaire. Relative level of IL-1mRNA. Timepoint: Before the beginning of the intervention (beginning of the study), the first day and the third day, and the time of discharge. Method of measurement: Sampling from patient's blood and filling in the questionnaire. Relative level of ROR-. Timepoint: Before the beginning of the intervention (beginning of the study), the first day and the third day, and the time of discharge. Method of measurement: Sampling from patient's blood and filling in the questionnaire. Relative level of T-bet mRNA. Timepoint: Before the beginning of the intervention (beginning of the study), the first day and the third day, and the time of discharg. Method of measurement: Sampling from patient's blood and filling in the questionnaire. Shahid Beheshti University of Medical Sciences Approved 2018-09-04 Ethics committee of Shahid Beheshti University of Medical Sciences Vel'yanjak Ave Shahid Beheshti University Tehran Tehran Iran (Islamic Republic of)