IRCT20190114042360N1 IRCT 2019-08-19 Hamedan University of Medical Sciences Study of four conservative treatment of osteoarthritis Comparative study of four conservative treatments for patients with knee osteoarthritis 2019-06-22 anticipated 120 Complete https://irct.ir/trial/36808 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are randomly assigned to one of four groups: the first group (A) receives 200 mg of celecoxib twice daily with intradermal injection of placebo (distilled water). The second group (B) is the same as the intracellular injection of celecoxib A 40-mm dipomedulum ampoule is used jointly. The third group (C) received celecoxib 200 mg twice daily with an injection of hyaluronic acid (a medicine containing 10 mg in 2.5 cc). The fourth group (D) of celecoxib with the same dose was injected with depotomeric ampoules, hyaluronic acid Combination). The 8th block means that the first patient is treatment A, the second patient treatment C, the patient D treatment, the fourth patient B treatment, the patient the treatment B, the sixth patient D treatment, the seventh patient C treatment, the eighth patient A, and until the end of the work Until all samples are completed, Blinding description: In this study, the researcher only receives the received code of the injected drug into the knee joint and carries out follow-up follow-up. 3 Osteoarthritis. Intervention 1: Control group: Injection of placebo in the knee. Intervention 2: Intervention group: First intervention group: Injection of Ampule-40, 1 vial of 1 ml of pharmaceutical Exir Company-Iran in knee. Intervention 3: Intervention group: Second Intervention group: Injection of Ampule-40, 1 vial of 1 ml of pharmaceutical Exir Company-Iran in knee and Injections of 20 mg 2 ml intrajoint hyaline ampoule made by Fidia Italy. Intervention 4: Intervention group: Third intervention group: Injections of 20 mg 2 ml intrajoint hyaline ampoule made by Fidia Italy. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information