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IRCT20160430027677N11 IRCT 2019-01-22 Oroumia University of Medical Sciences Evaluation the effect of pregabalin on succinylcholine fasciculation and myalgia The effect of pregabalin on the prevention of succinylcholine-induced fasciculation and myalgia 2016-11-21 anticipated 100 Complete https://irct.ir/trial/36697 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients will be randomly assigned into two groups of pregabalin 300 mg (group PG) and placebo (group P) using Random Allocation Software 2.0, and the target codes will be written and placed in sealed envelopes with sequential allocation using double-blind method, Blinding description: The drug will be administered by the nurse in the ward and at the time of admission, the anesthesiologist will be unaware of which patient will be assigned to which group. Drug containers will be identical and only the nurse will knew about the contents of each of them, and finally, after collecting information from the anesthesia residents, the anesthesiologist will be informed of the group each patient will be assigned to. 2-3 fasciculation. Intervention 1: Intervention group: will be received Pregabalin 300 mg tablet oral placebo 30 minutes before surgery. Intervention 2: Control group: will be received placebo 30 minutes before surgery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Shahryar Sane
Emergrnt Street, Resalat Avenue
Urmia Iran (Islamic Republic of) 5714783734 +98 44 3223 4897 sanesh@umsu.ac.ir Oroumia University of Medical Sciences scientific Shahryar Sane
Emergrnt Street, Resalat Avenue
Urmia Iran (Islamic Republic of) 5714783734 +98 44 3223 4897 sanesh@umsu.ac.ir Oroumia University of Medical Sciences Iran (Islamic Republic of) aged 20 to 60 years old American Society of Anesthesiologists class I and II 20 years 60 years Both Patients with BMI above 25 kg/m² history of central nervous system disease renal dysfunction history of allergy to any of the drugs used during the study history of peptic ulcer disease and antacid therapy patients who used analgesic drug within 24 hours before surgery used any kind of sedative drug patients with a history of taking antidepressants and calcium channel blockers patients who had contraindication for succinylcholine patients whose laparoscopic cholecystectomy will be replaced with open cholecystectomy R25.3 Fasciculation Prevention Placebo Intervention group: will be received Pregabalin 300 mg tablet oral placebo 30 minutes before surgery. Control group: will be received placebo 30 minutes before surgery. Fasciculation. Timepoint: Immediately after injection of succinylcholine. Method of measurement: visual analog scale. Incidence of myalgia. Timepoint: 6, 12, 18, and 24 hours after surgery. Method of measurement: visual analog scale. Severity of myalgia. Timepoint: 6, 12, 18, and 24 hours after surgery. Method of measurement: visual analog scale. Oroumia University of Medical Sciences Approved 2016-10-26 Ethics commitee of Urmia University of Medical Sciences Emergent Street, Ershad Avenue Urmia West Azarbaijan Iran (Islamic Republic of)