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IRCT20130710013947N9 IRCT 2019-01-14 Rasht University of Medical Sciences The effects and side effects of Cinnarizine and Bethahistine in The Treatment of Patients with Acute Peripheral Vertigo The effects and side effects of Cinnarizine and Bethahistine in The Treatment of Patients with Acute Peripheral Vertigo 2019-02-20 anticipated 150 Complete https://irct.ir/trial/36500 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients were randomly assigned to a study based on grading visits and inclusion criteria according to the required sample population. In the first of study, they were placed in a lacquer envelope and sealed in the research center. They were randomly assigned into 3 groups (betahistine and Placebo groups) Group B (Cinnarizine and Placebo Group) and Group C (Betahistine and cinnarizine) Random Allocation. The study blindness is done in such a way that random sequences are placed in closed envelopes at the nursing station, and the individual's in-person-based sequencing is carried out by the nurse of the department and the specialist does not know about the treatment. No information is available from the pocket. The nurse do not know anything about the illness level . The method of measuring vertigo symptoms is based on a questionnaire attached to the proposal (by a third person who has not played any role in the design of the research). Therefore, this study is a randomized, double blinded clinical trial study, Blinding description: Patients were randomly assigned to a study based on grading visits and inclusion criteria according to the required sample population. In the first of study, they were placed in a lacquer envelope and sealed in the research center. They were randomly assigned into 3 groups (betahistine and Placebo groups) Group B (Cinnarizine and Placebo Group) and Group C (Betahistine and cinnarizine) Random Allocation. The study blindness is done in such a way that random sequences are placed in closed envelopes at the nursing station, and the individual's in-person-based sequencing is carried out by the nurse of the department and the specialist does not know about the treatment. No information is available from the pocket. The nurse do not know anything about the illness level . The method of measuring vertigo symptoms is based on a questionnaire attached to the proposal (by a third person who has not played any role in the design of the research). Therefore, this study is a randomized, double blinded clinical trial study. 3 Benign Positional Vertigo. Intervention 1: Intervention group: The first group was treated with cinnarizine 25 mg and placebo 3 times a day. Intervention 2: Intervention group: The second group received 1 week treatment with betahistine 8 mg and placebo 3 times a day. Intervention 3: Intervention group: The third group was treated for 1 week with 1 betahistine 8 mg and cinnarizine 25 mg 3 times daily. Yes - There is a plan to make this available What will be shared: All data will published as article in journal without patients name When: After publication in journal To whom: After publication in journal Conditions: After publication in journal Where to obtain: It will be free or not depend on journal policy How to obtain: It will be free or not depend on journal policy Comments:
public Dr Peyman Asadi
parastar street, rasht
Rasht Iran (Islamic Republic of) 4144666949 +98 13 3322 2444 payman.asadi@yahoo.com Rasht University of Medical Sciences scientific Dr peyman Asadi
parastar street, rasht
Rasht Iran (Islamic Republic of) 4144666949 +98 13 3322 2444 payman.asadi@yahoo.com Rasht University of Medical Sciences Iran (Islamic Republic of) Age more than 18 years old Age less than 60 years old patients referred with Benign Positional Vertigo (BPV) Did not use drug before reference 18 years 60 years Both Meniere syndrome Vertigo caused by untreated primary organ disease Pregnancy Patients use Benzodiazepines, CNS suppressant, Barbiturates History of internal and middle ear surgery Migraine headaches Headache at the time of study A history of mental or neurological illness Gastric ulcer and digestive problems H81.1 Benign paroxysmal Positional vertigo Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: The first group was treated with cinnarizine 25 mg and placebo 3 times a day Intervention group: The second group received 1 week treatment with betahistine 8 mg and placebo 3 times a day Intervention group: The third group was treated for 1 week with 1 betahistine 8 mg and cinnarizine 25 mg 3 times daily Rate of positional vertigo. Timepoint: At first, 3rd days and 1 week later. Method of measurement: Visual Analog Scale. Significance improvement. Timepoint: 3rd days and 1 week later after treatment. Method of measurement: Mean Vertigo Score (MVS). Rasht University of Medical Sciences Approved 2018-12-31 Ethics committee of Guilan University of medical Sciences Namjoo Street, Rasht, Guilan, Iran Rasht Guilan Iran (Islamic Republic of)