IRCT20180922041084N3 IRCT 2019-03-01 Shiraz University of Medical Sciences Comparison of infusion of labetalol and lidocaine during tympanoplasty surgery Comparative evaluation between two methods of induced hypotension including infusion of labetalol and lidocaine during tympanoplasty surgery 2019-04-09 anticipated 64 Complete https://irct.ir/trial/36403 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patient randomization will be done based on the table extracted from www.randomization.com site in the form of blocks of size 4, Blinding description: Patients are coded by the researcher based on the randomized list. Then the drug is prepared based on the list and will be provided to the anesthesia expert to assign to each patient. In this way, the researcher, the patient and anesthesia expert and evaluators will be kept blind. 2-3 Induced Hypotension. Intervention 1: Intervention group 1: in first group immediately after induction and intubation and before injection and surgical incision, labetalol 0.5 % (manufactured by Exire company) 20mg bolous during 2 minutes in supine position will be injected. Then infusion will be continued at the dose of 0.5_2mg/min to max 300mg or reaching the proper pressure by syringe pump until the end of surgery. Intervention 2: Intervention group 2: In the second group, immediately after the induction and intubation and before the injection of anesthesia and incision by the surgeon, a bolous dose of lidocaine 1% (manufacture by Exire company) will be injected bolously at the dose of 1_2 mg/kg body weight during 2 minutes in supine position and after that it will be continued at the dose of 1.5mg/kg body weight until the end of the operation. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It is against our policy.