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IRCT20141209020258N93 IRCT 2019-01-09 Vice Chancellor For Research, Arak University Of Medical Science Comparison of therapeutic effects and its outcomes with morphine against methadone in combination with diazepam and haloperidol in cancer patients with severe and chronic pain referred to emergency ward. Comparison of therapeutic effects and its outcomes with morphine against methadone in combination with diazepam and haloperidol in cancer patients with severe and chronic pain referred to emergency ward. 2018-06-22 anticipated 92 Complete https://irct.ir/trial/36399 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization with random number in division of groups in two groups A and B.Randomized patients are divided into two groups.Randomized allocation in clinical trial studies refers to the process of dividing participants into different groups randomly. Randomizing gives each participant equal odds for being placed in each of the groups.The candidate patients who enter the study are randomly assigned to the randomly assigned table of randomly assigned to the two groups, Blinding description: This study is clinical trial.Outcome elevator and analyzer are blind (double blind).Outcome elevator and analyzer don't aware from grouping. 2-3 Cancer. Intervention 1: Intervention group: We inject 5 milligram Metadon and 5 milligram Haloperidol in muscular and 10 milligram Diazpam intravenous slowly for 5 minute in first group. Intervention 2: Intervention group: We inject slowly 5 milligram Morphine sulphat intravenous. Yes - There is a plan to make this available What will be shared: When we publish article in journal When: After the article is published To whom: researcher in university Conditions: If there are additional questions Where to obtain: Dr Simin najafgholian How to obtain: They have to write letters to the professors and the university Comments:
public Dr Ramin Parvizrad
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 parvizrad@arakmu.ac.ir Arak University of Medical Sciences scientific Dr Simin Najafgholian
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 najafgholian@arakmu.ac.ir Arak University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) All patients with metastatic disease of spine with pain complaints and scurvy of pain 7 and above referring to Emergency hospital of Amiralmomenin and Vali Asr arak Hospital Non-allergic to benzodiazepine and haloperidol no limit no limit Both Unsatisfied patients Decreased consciousness at the time of referral or during the study Blood pressure drop of SBP <90 at the time of referral or during the study There is any contraindication in the administration of opioid or Benzodiazepine or Haloperidol Patients with scores of pain less than 7 Oxygen saturation below 92% Heart rate above 90 or under 60 C80.9 Malignant neoplasm, primary site unspecified Treatment - Drugs Treatment - Drugs Intervention group: We inject 5 milligram Metadon and 5 milligram Haloperidol in muscular and 10 milligram Diazpam intravenous slowly for 5 minute in first group. Intervention group: We inject slowly 5 milligram Morphine sulphat intravenous. Pain. Timepoint: 1 and 24 hours after intervention. Method of measurement: Visual analog scale. Patient satisfaction. Timepoint: 24 hours after intervention. Method of measurement: observation. Side effect of drugs. Timepoint: After intervention. Method of measurement: Observation. Vice Chancellor For Research, Arak University Of Medical Science Approved 2018-06-10 Ethics Committe Arak University Of Medical Sciences Research Center, Payambar Azam Complex, Basij square, Sardasht, Arak Arak Markazi Iran (Islamic Republic of)