IRCT20181224042091N1 IRCT 2019-02-27 Mashhad University of Medical Sciences Evaluation of the effect of hormone therapy in breast cancer before surgery Comparison of the effect of letrozole and neoadjuvant cheotherapy with chemotherapy alone on clinical response in advanced hormonal breast cancer 2019-03-01 anticipated 48 Complete https://irct.ir/trial/36226 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: simple randomization. 3 Breast cancer. Intervention 1: Intervention group: Neoadjuvant patients treated with doxorubicin chemotherapy (60mg / m2) and cyclophosphamide (2600mg / m 2) every 2 weeks for 4 cycles, followed by paclitaxol (175mg / m 2) every 2 weeks for 4 cycles, and letrozole 1 per day , Patient with pre-menopausal zoladex 3.6 mg every 28 days of subcutaneous administration 2 weeks before treatment. Intervention 2: Control group: Only chemotherapy is given. Yes - There is a plan to make this available What will be shared: General information of patients and the main outcome and analyzed data When: After completing sample size To whom: People working at university centers Conditions: In the case of access, they do not have any analysis and interpretation before the article is published Where to obtain: Email:mozahebz@mums.ac.ir How to obtain: After requesting and reasoning, the need for this information and how to use this information are available within 1 week, if available. Comments: