]>
IRCT20181219042046N1 IRCT 2019-04-19 Tehran University of Medical Sciences Effect of non-narcotic agents on postoperative analgesia Comparative study of effect of second dose of pregabalin, acetaminophen, naproxen and dextromethorphan on postoperative analgesia 2019-04-21 anticipated 60 Complete https://irct.ir/trial/36134 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are divided into two groups randomly according to the random number table to receive the second dose after being transferred to the ward; Accordingly, each patient is assigned a random number (individual or paired) randomly. The combination of the drug and the placebo will be packed in the same white envelopes as the research guide and will be provided to the prescribes for the second dose. A group that has an individual number receives a second dose of the drug compound and the other group (paired numbers) receives the placebo. The only person who knows the contents of the envelope is the research guide and the patients, the administrators and outcome evaluator are unaware, Blinding description: The drug combination and the placebo will be packed in the same white envelopes as the research guide and will be provided to the prescribes for the second dose. 3 Postoperative pain. Intervention 1: Intervention group: Administration of the second dose of the combination of Cap Pregabalin 300mg, Tab Acetaminophen 1g, Tab Naproxen 500mg and Tab Dextromethorphan 30 mg for postoperative analgesia. Intervention 2: Control group: Prescribing a placebo instead of a second dose. Yes - There is a plan to make this available What will be shared: severity and type pain When: 6 month after outcomes released To whom: academic and scientific persons Conditions: There is no limit to the use of data or documentation due to unidentifiable patient information. Where to obtain: Majid Amini aminimajid1990@gmail.com How to obtain: After receiving an application via email, it will be answered for one week. Comments:
public Majid Amini
Imam khomeini Hospital Complex- Keshavarz Blvd - Tehran - Iran
Tehran Iran (Islamic Republic of) 1417933791 +98 31 3441 5047 aminimajid1990@gmail.com Tehran University of Medical Sciences scientific Majid Amini
Imam khomeini Hospital Complex- Keshavarz Blvd - Tehran - Iran
Tehran Iran (Islamic Republic of) 1417933791 +98 31 3441 5047 aminimajid1990@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) All patients with ASA-PS score of one to three who are on the list of surgeries: Nephrectomy, Cystetomy, Prostatectomy, Colectomy, Vippel and RPLND and aged 18 to 80 years 18 years 80 years Both Drug addicts Any contraindication and allergy to Pregabalin, Acetaminophen, Naproxen and Dextromethorphan Patients who are not extubated after surgery T40.0 Poisoning by, adverse effect of and underdosing of opium Treatment - Drugs Treatment - Drugs Intervention group: Administration of the second dose of the combination of Cap Pregabalin 300mg, Tab Acetaminophen 1g, Tab Naproxen 500mg and Tab Dextromethorphan 30 mg for postoperative analgesia Control group: Prescribing a placebo instead of a second dose Pain severity by using UPAT (universal pain assessment tool). Timepoint: Pain measurement at 0, 2, 4, 6, 8, 12, 24, 48 hours after surgery. Method of measurement: UPAT (universal pain assessment tool). 29/5000Type of pain: somatic or neuropathic. Timepoint: Evaluation at times 0, 2, 4, 6, 8, 12, 24 and 48 hours after surgery. Method of measurement: Descriptive history of the patient. Tehran University of Medical Sciences Approved 2018-04-18 Ethics Committee of Tehran University of Medical Sciences Imam Khomaini Hospital Complex, Keshavarz Blvd., Tehran, Iran Tehran Tehran Iran (Islamic Republic of)