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IRCT20160717028967N9 IRCT 2019-01-01 Vice chancellor for research, Avicenna infertility center The effect of long term GnRH agonist before frozen embryo transfer in pregnancy outcomes in women with adenomyosis The effect of long term Gnrh agonist before frozen embryo transfer in pregnancy outcomes in women with adenomyosis in avecinna infertility center in 2‌‌ 018_2019 2019-03-01 anticipated 60 Complete https://irct.ir/trial/36103 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are divided into two equal groups (A and B) based on a randomized six-block table that is designed by Random allocation software. 2 People with Adenomyosis. Intervention 1: Intervention group: The GnRH agonist group treated with a 11.25 mg intramuscular Triptorelin in the 3th menstural cycle day and after 12 weeks hormone replacement therapy starts with estradiol valerate. Then subjects will be followed with serial transvaginal ultrasound and after reaching to the endometrial thickness of 7 mm, progesterone will be added to the treatment and after 3 to 5 days embryo transfer will be performed. Intervention 2: Control group: In the control group the standard treatment begins with a 21 days of low dose contraceptives from the 3th day of the menstural cycle and a 1.875 mg intramuscular dose of Triptorelin in the 21th day of menstural cycle and the hormone replacement therapy starts with estradiol valerate in the next menstural cycle. Then subjects will be followed with serial transvaginal ultrasound and after reaching to the endometrial thickness of 7 mm, progesterone will be added to the treatment and after 3 to 5 days embryo transfer will be performed. Yes - There is a plan to make this available What will be shared: I have no plans at this time When: I have no plans at this time To whom: I have no plans at this time Conditions: I have no plans at this time Where to obtain: I have no plans at this time How to obtain: I have no plans at this time Comments:
public Dr. Soheila Ansaripour
No 97, Yakhchal junction, Shariati street, Avecinna infertility center,Tehran, Iran.
Tehran Iran (Islamic Republic of) 1941913114 +98 0982123519 Soh.ansaripour@gmail.com Avecinna infertility center scientific Dr. Soheila Ansaripour
No 97, Yakhchal junction, Shariati street, Avicenna infertility center,Tehran, Iran.
Tehran Iran (Islamic Republic of) 1941913114 +98 21 23519 Soh.ansaripour@gmail.com Avicenna infertility center Iran (Islamic Republic of) Having at least 2 criteria in sonography Age between 20 to 40 years old The candidate for frozen embryo transfer The embryo has a quality A or blastocyst 20 years 40 years Female Recurrent abortion Azospermia in sperm analysis of male partner Uncontrolled medical condition Abnormal karyotype Uterine abnormal anatomy Immune and coagulation dysfunction Using immune suppressive medications Using immune suppressive medications Using another treatments for improvement of fertility success rate N80 Endometriosis Treatment - Drugs Treatment - Drugs Intervention group: The GnRH agonist group treated with a 11.25 mg intramuscular Triptorelin in the 3th menstural cycle day and after 12 weeks hormone replacement therapy starts with estradiol valerate. Then subjects will be followed with serial transvaginal ultrasound and after reaching to the endometrial thickness of 7 mm, progesterone will be added to the treatment and after 3 to 5 days embryo transfer will be performed. Control group: In the control group the standard treatment begins with a 21 days of low dose contraceptives from the 3th day of the menstural cycle and a 1.875 mg intramuscular dose of Triptorelin in the 21th day of menstural cycle and the hormone replacement therapy starts with estradiol valerate in the next menstural cycle. Then subjects will be followed with serial transvaginal ultrasound and after reaching to the endometrial thickness of 7 mm, progesterone will be added to the treatment and after 3 to 5 days embryo transfer will be performed. Pregnancy rate. Timepoint: 14 and 16 days after embryo transfer. Method of measurement: Beta test. Clinical pregnancy rate. Timepoint: 6th week of pregnancy. Method of measurement: With sonography. Ongoing pregnancy rate. Timepoint: 7th week of pregnancy. Method of measurement: With sonography. Abortion rate before 12 weeks. Timepoint: 12th week of pregnancy. Method of measurement: With sonography. Vice chancellor for research, Avicenna infertility center Approved 2018-11-20 Ethics committee of Avecinna infertility center No 97, Yakhchal junction, Shariati street, Avecinna infertility center. Tehran Tehran Iran (Islamic Republic of)