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IRCT20170513033946N5 IRCT 2019-01-19 Zanjan University of Medical Sciences Efficasy of transcranial direct current stimulation on dorsolateral prefrontal cortex on BDNF, IL-6, TNF-alpha Efficasy of transcranial direct current stimulation on dorsolateral prefrontal cortex on BDNF, IL-6, TNF-alpha 2018-06-22 anticipated 36 Complete https://irct.ir/trial/36081 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: By online web software, Blinding description: Subjects will be evaluated by another examiner Subjects will be assigned to groups without knowing about treatment groups. N/A Mental and behavioural disorders due to use of opioids. Intervention 1: Intervention group: There will be three groups. Two of them will be intervention groups and the other on will be sham group. One of the groups will receive Anodal tDCS treatment on R-DLPFC based on the protocol. This treatment consists of 10 sessions. Intervention 2: Intervention group: This treatment consists of 6 sessions within two weeks. One of the groups will receive Cathodal tDCS treatment on L-DLPFC based on the protocol. This treatment consists of 10 sessions. This treatment consists of 6 sessions within two weeks. Intervention 3: Intervention group: The third group will sham tDCS but will be called the placebo effect of tDCS. No - There is not a plan to make this available Justification or reason for not sharing IPD is Not complete
public Zakaria Eskandari
Arq square-Beheshti hospital
Zanjan Iran (Islamic Republic of) 45136-15788 +98 24 3354 4001 mohsendadashi@zums.ac.ir Zanjan University of Medical Sciences scientific Zakaria eskandari
Arq squre- Beheshti hospital
Zanjan Iran (Islamic Republic of) 45136-15788 +98 24 3354 4001 Mohsendadashi@zums.ac.ir Zanjan University of Medical Sciences Iran (Islamic Republic of) Having informed consent to participate in the research Methadone treatment for at least two weeks before the intervention Age 18- 50 years old Minimum grade education 18 years 50 years Male The absence of more than two sessions Suicidal thoughts or dangers that It is not possible to keep the dosage fixed Having severe psychiatric disorders such as schizophrenia Consuming multiple substance History of injury to the head History of epileptic seizures F11.1 Opioid abuse with opioid-induced mood disorder Treatment - Devices Treatment - Other Treatment - Devices Intervention group: There will be three groups. Two of them will be intervention groups and the other on will be sham group. One of the groups will receive Anodal tDCS treatment on R-DLPFC based on the protocol. This treatment consists of 10 sessions. Intervention group: This treatment consists of 6 sessions within two weeks. One of the groups will receive Cathodal tDCS treatment on L-DLPFC based on the protocol. This treatment consists of 10 sessions. This treatment consists of 6 sessions within two weeks. Intervention group: The third group will sham tDCS but will be called the placebo effect of tDCS. Brain- derived neurotrophic factor (BDNF). Timepoint: pretest-post test. Method of measurement: Eliza kit. Interleukin 6 (IL-6). Timepoint: pretest-post test. Method of measurement: Eliza kit. Tumor necrosis factor-( TNF-a). Timepoint: pretest-post test. Method of measurement: Eliza kit. Quantitative EEG (QEEG). Timepoint: pretest-post test. Method of measurement: Mitsar set. BART Impassivity. Timepoint: pretest- post test. Method of measurement: BART Impassivity questionnaire. Craving. Timepoint: pretest- post test. Method of measurement: Desires for Drugs Questionnaire (DDQ). Sub scale anxiety -DASS. Timepoint: pretest- post test. Method of measurement: depression sub scale(DASS). Decision making ablity. Timepoint: pretest-post test. Method of measurement: IUWA Gambling Task. Zanjan University of Medical Sciences Approved 2018-08-14 Ethics committee of Zanjan University of Medical Sciences ZUMS Central Office: Azadi Square, Zanjan, Zanjan Zanjan Zanjan Iran (Islamic Republic of)