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IRCT20120215009014N257 IRCT 2019-01-13 Hamedan University of Medical Sciences Effect of topical N-acetyl cysteine cream versus topical corticosteroid on treatment of chronic eczema of the hand Effect of topical N-acetyl cysteine cream versus topical corticosteroid on treatment of chronic eczema of the hand: a double-blind randomized clinical trial 2018-12-31 anticipated 70 Complete https://irct.ir/trial/35897 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random assignment of the patients to the intervention and control groups through the drawing of lots. To do this, we prepare two sheets and write "intervention" on one sheet and "control" on another. Then, by referring each patient, one of the sheets will be randomly taken and the patient will be assigned to the intervention or control group, Blinding description: The shape of the medications will be perfectly the same in the two groups. Therefore, patients will be unaware of the type of intervention. The physician who will examine the patients will not be aware of the intervention. Therefore, the trial will be run as double-blind. 2 Eczema. Intervention 1: Intervention group: Topical Flucinolone cream 25% (Manufactured by Behvarzan Pharmaceutical Company) plus topical oatmeal cream 1% (Manufactured by the laboratory of School of Pharmacy, Hamadan University of Medical Sciences) for 2 weeks and then topical oatmeal cream 1% alone for 4 weeks. Intervention 2: Control group: Topical Flucinolone cream 25% (Manufactured by Behvarzan Pharmaceutical Company) plus topical placebo cream (Manufactured by the laboratory of School of Pharmacy, Hamadan University of Medical Sciences) for 2 weeks and then topical placebo cream alone for 4 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situations and the results of the study as well as approval of the financial supporting organization.
public Masa Hojati
School of Pharmacy, Hamadan University of Medical Sciences, Shahid Fahmideh Ave.
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3838 0572 hojati90@gmail.com Hamedan University of Medical Sciences scientific Dr. Maryam Mehrpooya
School of Pharmacy, Hamadan University of Medical Sciences, Shahid Fahmideh Ave.
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3838 0572 m_mehrpooya2003@yahoo.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Age of 12 to 65 years; Chronic eczema of the hand 12 years 65 years Both Pregnancy or breastfeeding; Other concurrent skin lesions such as psoriasis; Immunodeficiency L20.84 Intrinsic (allergic) eczema Treatment - Drugs Placebo Intervention group: Topical Flucinolone cream 25% (Manufactured by Behvarzan Pharmaceutical Company) plus topical oatmeal cream 1% (Manufactured by the laboratory of School of Pharmacy, Hamadan University of Medical Sciences) for 2 weeks and then topical oatmeal cream 1% alone for 4 weeks Control group: Topical Flucinolone cream 25% (Manufactured by Behvarzan Pharmaceutical Company) plus topical placebo cream (Manufactured by the laboratory of School of Pharmacy, Hamadan University of Medical Sciences) for 2 weeks and then topical placebo cream alone for 4 weeks The severity of pruritus. Timepoint: Before the intervention and 2 and 6 weeks after the intervention. Method of measurement: By taking history. The severity of skin lesions. Timepoint: Before the intervention and 2 and 6 weeks after the intervention. Method of measurement: By clinical examination. Hamedan University of Medical Sciences Approved 2018-09-01 Ethics Committee of Hamadan University of Medical Sciences Vice-chancellor for Research and Technology, Hamadan University of Medical Sciences, Shahid Fahmideh Ave Hamadan Hamadan Iran (Islamic Republic of)