]>
IRCT20180912041018N2 IRCT 2019-02-10 Tabriz University of Medical Sciences Study the Effect of Exercise Training and Supplementation of L-Arginine in elderly men Study the Effect of Concurrent Training and Supplementation of L-Arginine on SIRT6, FBS and Body Composition in Elderly men 2018-02-20 anticipated 44 Complete https://irct.ir/trial/35844 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Using NCSS PASS11 software, Procedure menu, DOE submenu, subjects were randomly will be divided into four equal-sized groups, Blinding description: Since Exercise training cannot be masked in a way as, for instance, pharmacological substances, so an important level of blinding in exercise science research remains with the data collectors. In this single-blind study, due to the nature of the method, blinding will be done in the information gathering stage by a person who is completely unaware of the presence of individuals in the groups. 3 aging. Intervention 1: Intervention group: First group of concurrent training+ supplement of l-arginine that in addition to the concurrent training, performed three sessions per week (coupled days), daily each subject received 1,000 mg of L-Arg capsule contain of L-arginine Hydrochloride, Microcrystalline Cellulose, P.V.P, Magnesium, Stearate after breakfast with full stomach. Intervention 2: Intervention group: secound, group of concurrent training+placebo, which in addition to implementing the exercise protocol three sessions per week for eight weeks, will also use placebo capsules similar to capsules of supplementary groups filled with maltodextrin. It should be noted that the investigator and subjects will not be informed of the contents of the capsule until the end of the protocol. Intervention 3: Intervention group: Third, group of supplement that for eight weeks, daily received 1,000 mg of placebo capsules .The capsules will have identical shape and appearance and contained L-Arg Hydrochloride, Microcrystalline Cellulose, P.V.P, Magnesium, Stearate (Karen Pharma & Food Supplement Co) Prepared from Karen Pharmaceutical Company PNC, code 6261405113328 approved by the Ministry of Health of Iran. Intervention 4: Control group: There was no intervention on them, only they were asked to continue their normal life. Yes - There is a plan to make this available What will be shared: The SPSS data used to support the findings of this study are available from the corresponding author upon request. When: The SPSS data used to support the findings of this study are available from the corresponding author upon request. To whom: The SPSS data used to support the findings of this study are available from the corresponding author upon request. Conditions: By authorizing the corresponding author and maintaining all the material and spiritual rights Where to obtain: The SPSS data used to support the findings of this study are available from the corresponding author upon request. How to obtain: The SPSS data used to support the findings of this study are available from the corresponding author upon request. Comments:
public Neda Gilani
Niayesh, Tabriz University of Medical Sciences
Tabriz Iran (Islamic Republic of) 5166614711 +98 41 3334 0308 neda.gilani@gmail.com Tabriz University of Medical Sciences scientific Rouhollah Haghshenas
standard square
Semnan Iran (Islamic Republic of) 3513119111 +98 23 3336 3494 rhm@semnan.ac.ir Semnan University Iran (Islamic Republic of) males in range of 60≤age≤75 years Being able to do exercise movements 60 years 75 years Male Having systematic strength training last 6 months (At least more than one session per week) having to cardiovascular disease and joint and bone problems Bone fractures Use of any kind of antioxidant supplements Rehabilitation Placebo Other Other Intervention group: First group of concurrent training+ supplement of l-arginine that in addition to the concurrent training, performed three sessions per week (coupled days), daily each subject received 1,000 mg of L-Arg capsule contain of L-arginine Hydrochloride, Microcrystalline Cellulose, P.V.P, Magnesium, Stearate after breakfast with full stomach. Intervention group: secound, group of concurrent training+placebo, which in addition to implementing the exercise protocol three sessions per week for eight weeks, will also use placebo capsules similar to capsules of supplementary groups filled with maltodextrin. It should be noted that the investigator and subjects will not be informed of the contents of the capsule until the end of the protocol. Intervention group: Third, group of supplement that for eight weeks, daily received 1,000 mg of placebo capsules .The capsules will have identical shape and appearance and contained L-Arg Hydrochloride, Microcrystalline Cellulose, P.V.P, Magnesium, Stearate (Karen Pharma & Food Supplement Co) Prepared from Karen Pharmaceutical Company PNC, code 6261405113328 approved by the Ministry of Health of Iran. Control group: There was no intervention on them, only they were asked to continue their normal life Sirtuin-6. Timepoint: Measuring Sirtuin-6 in the start of the study and 48 hours after the last training session. Method of measurement: Sirtuin6 concentrations assaye in plasma according to the manufacturers’ instructions using ELISA kits specific for human. Glucose. Timepoint: Measuring Glucose in the start of the study and 48 hours after the last training session. Method of measurement: برای اندازه گیری گلوکز خون ازروش آنزیماتیک کالری متری و کیت شرکت پارس آزمون ایران و به ترتیب با دقت و حساسیت 1.3 % و 1 mg/dl استفاده خواهد شد. Body Composition. Timepoint: Measuring Body Composition in the start of the study and 48 hours after the last training session. Method of measurement: Body Composition will be calculated as weight (kg) divided by the square of the height (m2). Tabriz University of Medical Sciences Approved 2018-03-05 ethics committee of Tabriz University of Medical Sciences Niayesh tabriz East Azarbaijan Iran (Islamic Republic of)