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IRCT20181210041912N1 IRCT 2019-01-14 Kerman University of Medical Sciences Comparison the effects of Donepezil, Galantamine,Rivastigmine and Memantine on vascular dementia. Comparison the effects of Donepezil, Galantamine,Rivastigmine and Memantine on transcranial Doppler sonography and MMSE in patients with vascular dementia. 2018-12-22 anticipated 44 Complete https://irct.ir/trial/35813 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, 44 patients with vascular dementia referring to a neurologist were randomly divided into 4 groups of 11 patients. The randomization method is simple and How to create a sequence. is random, Blinding description: This study was carried out for patients with vascular dementia at the onset of ultrasound and MMSE intervention and then referred to one of the contributors who are unaware of the type of medication. After receiving the code, the patient is treated with one of the medications in the uncertain packing (A, B, C, D) until the end of the intervention, which is repeated in the above procedures. 2 Vascular Dementia. Intervention 1: Intervention group: Donpezil starts at 5mg / day and increases to 10mg / day within two weeks and lasts up to three months. Intervention 2: Intervention group: Rivastigmine starts at 1.5mg twice daily and increases to 3mg twice a week within a week. Intervention 3: Intervention group: Memantine starts at 5mg daily and increases to 10mg per day in one week. Intervention 4: Intervention group: Galanthambon is given 8mg daily. Yes - There is a plan to make this available What will be shared: The results of transcranial doppler sonography that shares all the data after unidentifiable individuals. When: After completing the transcranial doppler sonography To whom: Faculty Members of Medical Universities across Iran Conditions: With written request for reuse of files Where to obtain: Postcode: Kerman, Kowsar Blvd, Shafa Hospital, Ali Farzan Moghadam Email:alifarzan57@yahoo.com phone number:09132512862 How to obtain: The written and formal request of the applicant who has been approved by the research assistant at the university of the applicant's workplace will be sent no later than one week later. Comments:
public Farhad Iranmanesh
Shafa Hospital, Kosar Blvd, Kerman
Kerman Iran (Islamic Republic of) ۷۶۱۸۷۵۱۱۵۱ +98 34 3211 5780 fpp_farhad@yahoo.com Kerman University of Medical Sciences scientific Kave Shafiee
Shafa Hospital, Kosar Blvd,Kerman
Kerman Iran (Islamic Republic of) ۷۶۱۸۷۵۱۱۵۱ +98 34 3211 5780 kshafiee@gmail.com Kerman University of Medical Sciences Iran (Islamic Republic of) Patients with vascular dementia in Kerman city no limit no limit Both Having any underlying condition other than diabetes, hypertension, hyperlipidemia, and ischemic heart disease, including history of depression and memory and speech impairment. Use of any medication, such as sedative medicines and substance abuse, except medicines for controlling diabetes, hypertension, hyperlipidemia, and ischemic heart disease. I63 occlusion and stenosis of cerebral and precerebral arteries (including truncus brachiocephalicus), resulting in cerebral infarction Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: Donpezil starts at 5mg / day and increases to 10mg / day within two weeks and lasts up to three months. Intervention group: Rivastigmine starts at 1.5mg twice daily and increases to 3mg twice a week within a week. Intervention group: Memantine starts at 5mg daily and increases to 10mg per day in one week. Intervention group: Galanthambon is given 8mg daily. Transcranial Doppler Sonography. Timepoint: Performing transcranial doppler sonography at the beginning of the study and three months after taking any of the donepezill, memantine, galanthamine or rivastigmine drugs. Method of measurement: Doppler Sonography machine. Mini Mental State Examination. Timepoint: Measurement of the MMSE at the beginning of the study and three months after the onset of consumption, which of the drugs donepezil, memantine, galantamine or rivastigmine. Method of measurement: By number from zero to thirty. Kerman University of Medical Sciences Approved 2018-12-10 Ethics Committee of Kerman University of Medical Sciences Campus of the University of Medical Sciences, the center of seven Alavi Gardens, Kerman Kerman Kerman Iran (Islamic Republic of)