]>
IRCT20181109041597N1 IRCT 2019-01-07 Mashhad University of Medical Sciences The frozen embryo transfer in infertile women with unsuccessful embryo transfer history. A clinical trial to compare the frozen embryo transfer (FET) via letrozole and recombinant human FSH (rhFSH) induction with GnRH agonist and estradiol valerate in infertile women with unsuccessful embryo transfer history 2018-12-22 anticipated 142 Complete https://irct.ir/trial/35576 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Totally 142 women with unsuccessful embryo transfer history at the Milad Fertility Clinic, Mashhad, were chosen. The participants were allocated into two groups of intervention and control using the table of random numbers based on computer programs, Blinding description: Women with unsuccessful embryo transfer history at the Milad Fertility Clinic, Mashhad, were chosen. In this single-blind study, the data collector was blind to group assignment and the type of treatment. 2-3 Female infertility. Intervention 1: Intervention group: The intervention group will receive 2.5 mg of letrozole in cycle day 3 for 5 days and 75 ml of IU rhFSH in cycle day 9. Intervention 2: Control group: The control group will receive 500 μg of GnRH agonist in cycle day 21 and 4 mg of estradiol valerate in next cycle day 3. Yes - There is a plan to make this available What will be shared: The total data to be included are the primary and secondary effects to be shared. When: 6 months after printing results To whom: Our data will only be available to researchers working in science center and university. Conditions: Our data will be available for scholars working in science center and university. Where to obtain: Elnaz Zohdi provides the analysis code to the applicants via email: zohdie961@mums.ac.ir How to obtain: Data collection was done for 10 months, data were collected one month, statistical analysis of one month, information dissemination as a article six months. Comments:
public Elnaz Zohdi
Milad Fertility Clinic, East Razi Street
Mashhad Iran (Islamic Republic of) 9135913556 +98 51 3853 4021 zohdie961@mums.ac.ir Mashhad University of Medical Sciences scientific Elnaz Zohdi
Milad Fertility Clinic, East Razi Street
Mashhad Iran (Islamic Republic of) 9135913556 +98 51 3853 4021 zohdie961@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Age range of 22-40 years History of more than twice unsuccessful embryo transfer The male does not have severe infertility 18 years 35 years Female Severe endometriosis stage 3 and 4 Fibroma >4 cm Non-frozen-thawed embryo transfer Necrotic embryonic N97 Female infertility Treatment - Other Treatment - Other Intervention group: The intervention group will receive 2.5 mg of letrozole in cycle day 3 for 5 days and 75 ml of IU rhFSH in cycle day 9. Control group: The control group will receive 500 μg of GnRH agonist in cycle day 21 and 4 mg of estradiol valerate in next cycle day 3. Clinical pregnancy. Timepoint: Two and six weeks after embryo transfer. Method of measurement: Human chorionic gonadotropin (hCG) test and transvaginal sonography. Mashhad University of Medical Sciences Approved 2018-11-01 Ethics Committee of Mashhad University of Medical Sciences Vice Chancellor for Research, Mashhad University of Medical Sciences, Ghoreishi building, Daneshgah Street Mashhad Razavi Khorasan Iran (Islamic Republic of)