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IRCT20120801010471N4 IRCT 2019-01-14 Sanandaj University of Medical Sciences Effect of Dexmedetomidine on postoperative shivering after general anesthesia for appendectomy Effect of Dexmedetomidine on postoperative shivering after general anesthesia for appendectomy 2017-04-21 anticipated 90 Complete https://irct.ir/trial/35341 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Other, Purpose: Treatment, Randomization description: Simple randomization, Blinding description: The personnel that fulfill the questionnaire , nurse,anesthesiologist, data analysand did not know the patients. 3 Shivering after appendectomy. Intervention 1: Intervention group: Fentanyl 2µ/kg as a premedication, Thiopental sodium:5mg/kg and succinylcholin: 1.5mg/kg as induction of anesthesia were administered. Maintenance of anesthesia consists of Isoflurane 1.3 VOL% plus N2O and oxygen in the same concentration (3 L/min). The operation room was similar in all of our patients. The environment and checked for similar light, environmental temperature, drugs and liquids were kept in same rooms with same temperature.Intra venous fluid was infused 7cc/kg Ringer 5-7 minutes before induction of anesthesia. Pre oxygenation by 5-6 liter oxygen by anesthetic mask were done in all patients. Intra venous maintenance was 4cc/kg/h plus 3cc/kg instead of every milliliter of bleeding. Bleeding calculated by gathering the gases in the operation field and the blood in the suction bottle. Temperature was measured base on tympanic membrane temperature in at minutes baseline time,5,15,30,60 after induction of anesthesia.We monitored non invasive blood pressure, puls oximetery, EKG monitoring (lead 2). We administered 1µ/kg dexmedtomedin intravenously 20 minutes before induction of anesthesia during 10 minutes and slowly (1µ/kg diluted in 10cc streel water)in intervention group. Intervention 2: Control group: Fentanyl 2µ/kg as a premedication, thiopental.sodium:5mg/kg and succinylcholin: 1.5mg/kg as induction of anesthesia were administered. Maintenance of anesthesia consists of Isoflurane 1.3 VOL% plus N2O and oxygen in the same concentration (3 L/min).The operation room was similar in all of our patients. The environment, and checked for similar light, environmental temperature, drugs and liquids were kept in same rooms with same temperature.Intra venous fluid was infused 7cc/kg Ringer 5-7 minutes before induction of anesthesia.pre oxygenation by 5-6 liter oxygen by anesthetic mask were done in all patients. Intra venous maintenance was 4cc/kg/h plus 3cc/kg instead of every milliliter of bleeding. Bleeding calculated by gathering the gases in the operation field and the blood in the suction bottle.Temperature was measured base on tympanic membrane temperature in at minutes baseline time,5,15,30,60 after induction of anesthesia.We monitored non invasive blood pressure, puls oximetery, EKG monitoring (lead 2). Yes - There is a plan to make this available What will be shared: All the information in the article will be presented When: 2020 To whom: All people related to health Conditions: All people related to health Where to obtain: Milad Masaeli How to obtain: Email to Milad Masaeli and get it Comments:
public Milad Masaeli
Kowsar hospital, Pasdaran Ave, Azadi Square
Sanandaj Iran (Islamic Republic of) 66177-13446 +98 87 3361 1310 drmilmas@yahoo.com Sanandaj University of Medical Sciences scientific Milad Masaeli
Kowsar hospital,Pasdaran Ave,Azadi Square
Sanandaj Iran (Islamic Republic of) 66177-13446 +98 87 3361 1310 drmilmas@yahoo.com Sanandaj University of Medical Sciences Iran (Islamic Republic of) Emergent appendectomy patients 15 years 25 years Both Patients with peritonitis Past medical history of malignant hyperthermia Seizure Anaphylaxis Cardiovascular disease Diabetes mellitus Renal disease Substance use Liver disease Alcohol use Anti epileptic agent use Psychological disorders NSAIDs and usage of any other opioids or drugs for decreasing pain ASA more 2 Treatment - Drugs Treatment - Drugs Intervention group: Fentanyl 2µ/kg as a premedication, Thiopental sodium:5mg/kg and succinylcholin: 1.5mg/kg as induction of anesthesia were administered. Maintenance of anesthesia consists of Isoflurane 1.3 VOL% plus N2O and oxygen in the same concentration (3 L/min). The operation room was similar in all of our patients. The environment and checked for similar light, environmental temperature, drugs and liquids were kept in same rooms with same temperature.Intra venous fluid was infused 7cc/kg Ringer 5-7 minutes before induction of anesthesia. Pre oxygenation by 5-6 liter oxygen by anesthetic mask were done in all patients. Intra venous maintenance was 4cc/kg/h plus 3cc/kg instead of every milliliter of bleeding. Bleeding calculated by gathering the gases in the operation field and the blood in the suction bottle. Temperature was measured base on tympanic membrane temperature in at minutes baseline time,5,15,30,60 after induction of anesthesia.We monitored non invasive blood pressure, puls oximetery, EKG monitoring (lead 2). We administered 1µ/kg dexmedtomedin intravenously 20 minutes before induction of anesthesia during 10 minutes and slowly (1µ/kg diluted in 10cc streel water)in intervention group. Control group: Fentanyl 2µ/kg as a premedication, thiopental.sodium:5mg/kg and succinylcholin: 1.5mg/kg as induction of anesthesia were administered. Maintenance of anesthesia consists of Isoflurane 1.3 VOL% plus N2O and oxygen in the same concentration (3 L/min).The operation room was similar in all of our patients. The environment, and checked for similar light, environmental temperature, drugs and liquids were kept in same rooms with same temperature.Intra venous fluid was infused 7cc/kg Ringer 5-7 minutes before induction of anesthesia.pre oxygenation by 5-6 liter oxygen by anesthetic mask were done in all patients. Intra venous maintenance was 4cc/kg/h plus 3cc/kg instead of every milliliter of bleeding. Bleeding calculated by gathering the gases in the operation field and the blood in the suction bottle.Temperature was measured base on tympanic membrane temperature in at minutes baseline time,5,15,30,60 after induction of anesthesia.We monitored non invasive blood pressure, puls oximetery, EKG monitoring (lead 2). Shivering scale. Timepoint: Immediately after general anesthesia, 5, 15, 30, and 60 minutes after general anesthesia. Method of measurement: Shivering was evaluated using a 5-point scale. The scale used was;0 = no shivering; 1 = observation of one or more of the following: piloerection, peripheral vasoconstriction, peripheral cyanosis without other causes, and/or no visible muscular activity; 2 = visible muscular activity confined to 1 muscle group; 3 = visible muscular activity in more than 1 muscle group; 4 = gross muscular activity involving the entire body. Pain Scale. Timepoint: 5,10,15,20. Method of measurement: Visual Analogue Scale. Sanandaj University of Medical Sciences Approved 2017-03-06 Ethics Committee of Kurdistan University of Medical Sciences Pardis of Kurdistan University of Medical scinece, Pasdaran Ave, Azadi Square Sanandaj Kurdistan Iran (Islamic Republic of)