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IRCT20150614022713N2 IRCT 2018-11-29 Mashhad University of Medical Sciences The effect of remote ischemic preconditioning in patients with acute myocardial infarction A clinical trial to compare the effectiveness of remote ischemic preconditioning and primary coronary percutaneous intervention on cardiovascular outcomes in patients with acute myocardial infarction 2018-12-22 anticipated 60 Complete https://irct.ir/trial/35319 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Sixty patients with acute myocardial infarction at the Department of Cardiology in Ghaem Hospital, Mashhad, Iran, were chosen. The participants were allocated into two groups of intervention and control using the table of random numbers based on computer programs, Blinding description: Patients with acute myocardial infarction at the Department of Cardiology, Ghaem Hospital, Mashhad, Iran, were chosen. In this double-blind study, the clinical care and data collector were blind to group assignment and the type of treatment. 2-3 Acute myocardial infarction. Intervention 1: Intervention group: The intervention group will receive remote ischemic preconditioning. In this method, a blood pressure cuff is fastened on one of the patient's organs before surgery, and the cuff is intermittently blown and drained to restrict blood flow and reestablish it. Intervention 2: Control group: The control group will receive primary coronary percutaneous intervention. In this method, a tube with a balloon at the end, called the catheter, is moved into the coronary artery toward the blockage. After the dilatation of the vessel, the balloon is evacuated, and the catheter is pulled out. Yes - There is a plan to make this available What will be shared: The total data to be included are the primary and secondary effects to be shared. When: 6 months after printing results To whom: Our data will only be available to researchers working in science center and university. Conditions: Our data will be available for scholars working in science center and university. Where to obtain: Masoud Sajjadi provides the analysis code to the applicants via email: sajjadim961@mums.ac.ir How to obtain: Data collection was done for 10 months, data were collected one month, statistical analysis of one month, information dissemination as a article six months. Comments:
public Masoud Sajjadi
Imam Reza Hospital, Imam Reza Square, Mashhad
Mashad Iran (Islamic Republic of) 9137913316 +98 51 3854 3031 sajjadim961@mums.ac.ir Mashhad University of Medical Sciences scientific Masoud Sajjadi
Imam Reza Hospital, Imam Reza Square, Mashhad
Mashhad Iran (Islamic Republic of) 9137913316 +98 51 3854 3031 sajjadim961@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Age higher than 20 years An elapse of 12 hours form the primary diagnosis 20 years no limit Both Thrombolysis in myocardial infarction (TIMI) score of 2-3 Rentrop grade of >1 Need for coronary artery bypass graft Cardiogenic shock I21 Acute myocardial infarction Treatment - Other Treatment - Other Intervention group: The intervention group will receive remote ischemic preconditioning. In this method, a blood pressure cuff is fastened on one of the patient's organs before surgery, and the cuff is intermittently blown and drained to restrict blood flow and reestablish it. Control group: The control group will receive primary coronary percutaneous intervention. In this method, a tube with a balloon at the end, called the catheter, is moved into the coronary artery toward the blockage. After the dilatation of the vessel, the balloon is evacuated, and the catheter is pulled out. Major adverse cardiovascular events (i.e., mortality, second myocardial infarction, and stroke during admission). Timepoint: Before and 24 hours after the intervention. Method of measurement: Echocardiography. The reduction of ST-segment as an indicator of microvascular reperfusion. Timepoint: Before and 24 hours after the intervention. Method of measurement: Electrocardiogram (ECG). Thrombolysis in myocardial infarction flow. Timepoint: Before and 24 hours after the intervention. Method of measurement: Thrombolysis in Myocardial Infarction (TIMI) flow. Cardiac enzymes. Timepoint: Before and 24 hours after the intervention. Method of measurement: Blood test. Mashhad University of Medical Sciences Approved 2018-10-02 Vice Chancellor for Research, Mashhad University of Medical Sciences Vice Chancellor for Research, Mashhad University of Medical Sciences, Ghoreishi building, Daneshgah Street Mashhad Razavi Khorasan Iran (Islamic Republic of)