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IRCT20140624018210N9 IRCT 2019-04-13 Iran University of Medical Sciences Comparison of Nd-Yag fractional 1064 laser therapy with tranexamic acid mesotherapy efficacy versus Nd-Yag fractional 1064 laser therapy with oral tranexamic acid in patients suffering melasma. Comparison of Nd-Yag fractional 1064 laser therapy with tranexamic acid mesotherapy efficacy versus Nd-Yag fractional 1064 laser therapy with oral tranexamic acid in patients suffering melasma. 2018-06-22 anticipated 40 Complete https://irct.ir/trial/35079 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Factorial, Purpose: Treatment, Randomization description: patients were entered into each treatment group by computerized random selection with 1:1 ratio. each patient will choose an envelope from a box filled with 60 closed envelope which contains A or B code. (A --> first method and B--> second method), Blinding description: in this double-blind study, unlike the first researcher, second researcher, and analyzer just have access to A and B code. thus they do not know about the exact treatment. 3 melasma. Intervention group:. No - There is not a plan to make this available Justification or reason for not sharing IPD is there is no further information
public Elham behrangi
No. 4 , Orkide Ave. , Golhaye 2 Ave. , Elahi Ave. , Ayat Kashani Blvd.
Tehran Iran (Islamic Republic of) 1445613131 +98 21 6435 2391 Mahsa.shemshadi@gmail.com Iran University of Medical Sciences scientific Elham Behrangi
No.4, Orkide Ave., Golhaye2, Elahi Ave., Ayat Kashani Blvd.
Tehran Iran (Islamic Republic of) 1445613131 +98 21 6435 2391 Mahsa.shemshadi@gmail.com Iran University of Medical Sciences Iran (Islamic Republic of) patients should have the classical clinical features of melasma. skin type of patients should be I to IV. patients age should be between 18 to 50. 18 years 50 years Female Treatment - Drugs Intervention group: Brightening and improving the appearance of melasma by MASI score. Timepoint: Before the begin of the intervention and then 2, 4, 6, 8, 10, 12 weeks after the treatment in the studied groups. Method of measurement: The device used is Visioface, a scale used in study is melasma area severity index, and a questionnaire on the patient's healing process has also been used. Side effect of treatment , tolerability , satisfaction. Timepoint: 2, 4, 6, 8, 10, 12, 16 weeks after each treatment stage. Method of measurement: by questionnairr. Iran Univercity of Medical Sciences Approved 2018-06-11 Ethics committee of Iran Univercity of Medical Sciences Niyayesh Ave.,Sattar khan Blvd. Tehran Tehran Iran (Islamic Republic of)