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IRCT20150519022320N16 IRCT 2019-01-05 Rafsanjan University of Medical Sciences Comparative effect of two methods of relaxation and meditation on serum levels of IL-2, TNF-α, IL-17A and IL-23 cytokines Comparison of the effects of relaxation and meditation techniques on serum levels of IL-2, TNF-α, IL-17A and Il-23 in the patients with coronary artery disease who refer to the outpatient heart clinic in 2018 2018-10-23 anticipated 120 Complete https://irct.ir/trial/35010 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Basic scienece, Randomization description: According to the criteria for Inclusion, a list of 90 eligible patients is available. The names of people are then placed in vague envelopes, and a researcher puts the envelopes in 3 groups of 1, 2, 3, Then they are selected according to the lottery of 1,2,3 groups to meditation, relaxation and control groups, Blinding description: Tests are conducted by a researcher who does not know about the allocation of participants in study groups. N/A Coronary Artery Disease. Intervention 1: Intervention group 1: A relaxation program will be planned and implemented in seven stages for the relaxation group, the steps of which will be:1. Identify the muscles and muscle groups of the case, 2- Training on progressive muscle relaxation technique using its explanation and practical presentation by the researcher,3- Answering the patient's questions about the relaxation technique 4- Performing the technique by the researcher using an audio tape, or educational CD 5- Performing the technique by the patients along with the researcher, 6- Statement of difference in physical and mental feelings of samples after relaxation 7- Performing the technique by samples and under the supervision of the researcher. In relaxation, patients will be asked to first shrink and then loosen the muscles of the muscles of the foot to the muscles of the face, including 16 muscles. Patients relax their muscles by counting up to number 5 and then relaxing by counting up to 10.The same steps will be repeated for the legs, legs, thighs, abdomen, chest, hips, arms and forearms, arms, shoulders, neck, forehead, tongue and jaw, eyes and face until all of their bodies Loose integrated.At the same time, patients breathe deeply during relaxation. The state of choice for gradual relaxation is lying. The patient will perform this exercise until the difference between the contraction and the muscle tone is felt and expressed.In this way, the method will be taken and can take this method alone and using a tape. After ensuring the correct understanding and correctness of the procedure, audio cassettes and CDs will be provided to patients for the implementation of relaxation steps. And they spend three months (three times a week) one day in a row and for a half an hour under the supervision of the researcher (a total of 36 sessions). Intervention 2: Intervention group 2: To perform meditation, the patient is asked to be in a comfortable position and perform a deep inhale with 3 numbers and a deep exhalation with 4 numbers; Meditation will be performed for 8 weeks, 3 days a week, and 15 to 20 minutes per day in two steps in the morning and in the evening. Intervention 3: Control group: The control group includes patients who receive routine methods such as medical and medical services. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Confidentiality of information
public Tayebeh Mirzaei
Parastary Ave.
Rafsanjan Iran (Islamic Republic of) 7718796755 +98 34 3425 5900 t.mirzaei@rums.ac.ir Rafsanjan University of Medical Sciences scientific Mohammad Kazemi Arababadi
Parastary Ave.
Rafsanjan Iran (Islamic Republic of) 7718796755 +98 34 3425 5900 kazemi24@yahoo.com Rafsanjan University of Medical Sciences Iran (Islamic Republic of) Known coronary artery disease (based on medical records); History of admission in section CCU Expression of willingness to participate in the study 45 years 75 years Both History of heart failure History of mental illness or use of psychoactive drugs, The history of autoimmune diseases, allergies and immune-related diseases I25 Chronic ischemic heart disease Lifestyle Lifestyle N/A Intervention group 1: A relaxation program will be planned and implemented in seven stages for the relaxation group, the steps of which will be:1. Identify the muscles and muscle groups of the case, 2- Training on progressive muscle relaxation technique using its explanation and practical presentation by the researcher,3- Answering the patient's questions about the relaxation technique 4- Performing the technique by the researcher using an audio tape, or educational CD 5- Performing the technique by the patients along with the researcher, 6- Statement of difference in physical and mental feelings of samples after relaxation 7- Performing the technique by samples and under the supervision of the researcher. In relaxation, patients will be asked to first shrink and then loosen the muscles of the muscles of the foot to the muscles of the face, including 16 muscles. Patients relax their muscles by counting up to number 5 and then relaxing by counting up to 10.The same steps will be repeated for the legs, legs, thighs, abdomen, chest, hips, arms and forearms, arms, shoulders, neck, forehead, tongue and jaw, eyes and face until all of their bodies Loose integrated.At the same time, patients breathe deeply during relaxation. The state of choice for gradual relaxation is lying. The patient will perform this exercise until the difference between the contraction and the muscle tone is felt and expressed.In this way, the method will be taken and can take this method alone and using a tape. After ensuring the correct understanding and correctness of the procedure, audio cassettes and CDs will be provided to patients for the implementation of relaxation steps. And they spend three months (three times a week) one day in a row and for a half an hour under the supervision of the researcher (a total of 36 sessions). Intervention group 2: To perform meditation, the patient is asked to be in a comfortable position and perform a deep inhale with 3 numbers and a deep exhalation with 4 numbers; Meditation will be performed for 8 weeks, 3 days a week, and 15 to 20 minutes per day in two steps in the morning and in the evening. Control group: The control group includes patients who receive routine methods such as medical and medical services. Measuring the serum level of IL-17A. Timepoint: Before the start of the study and three months after the start of the study. Method of measurement: ELISA test. Measuring the serum level of IL-23. Timepoint: Before the start of the study and three months after the start of the study. Method of measurement: ELISA test. Measuring the serum level of IL-2. Timepoint: Before the start of the study and three months after the start of the study. Method of measurement: ELISA test. Measuring the serum level of TNF-α. Timepoint: Before the start of the study and three months after the start of the study. Method of measurement: ELISA test. Rafsanjan University of Medical Sciences Approved 2018-10-20 Ethics Committee on Research in Rafsanjan University of Medical Sciences Imam Ali Blvd, Central Office of the University of Medical Sciences Rafsanjan Kerman Iran (Islamic Republic of)