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IRCT20181028041485N1 IRCT 2019-02-12 Sanandaj University of Medical Sciences efficacy of diclofenac on pancreatitis efficacy of Diclofenac suppository on treatment of acute biliary pancreatitis 2017-03-20 anticipated 80 Complete https://irct.ir/trial/34933 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The randomization was Simple randomization. In this way, we divided the patients who had the inclusion criteria, into two groups with a closed envelope, Blinding description: Patients who will be present in the study will take a Suppository an will be supplemented by nurses based on which group they will be in, and the patient will not know what Suppository are given to him/her. In the case of the statistical advisor in the same way, only the data will be analyzed between the two groups and statistical advisor will not be known which group get the placebo. 3 Pancratitis. Intervention 1: Intervention group: Diclofenac Suppository 100 mg every 8 hours will be added until symptom improvement and the day before surgery. Intervention 2: Control group: Placebo Suppository every 8 hours will be added until the day before surgery. Yes - There is a plan to make this available What will be shared: All collected data is shareable and has no limitations When: The access period will be available after printing the results To whom: Researchers working in academia Conditions: There is no limitation Where to obtain: Deputy of Research of Kurdistan University of Medical Sciences How to obtain: The data are visible after request from the deputy of research and after confirmation of the request within one month Comments:
public Morteza Yousefi
Departmant of general surgery, Kowsar hospital, Pasdaran Blvd
Sanandaj Iran (Islamic Republic of) 661689581 +98 87 3361 1258 Yousefi.M@Muk.ac.ir Sanandaj University of Medical Sciences scientific Morteza Yousefi
Departmant of general surgery, Kowsar hospital, Pasdaran Blvd
Sanandaj Iran (Islamic Republic of) 6616894581 +98 87 3361 1258 Yousefi.M@Muk.ac.ir Sanandaj University of Medical Sciences Iran (Islamic Republic of) Acute pancreatitis, which in its definition should have at least two criteria of the following three criteria: a) pain in the upper abdomen, b) serum amylase or lipase> 3 times of normal, orc) acute pancreatitis features In computer tomography (CT) or magnetic resonance imaging (MRI) A biliary cause based on at least one of the following conditions: a) gallstone or sludge in the imaging (any type); b) common bile duct > 8 mm in patients <75 years of age or> 10 mm in patients> 75 years of age. C) Alanine aminotransferase (AST) more than twice as normal; Conscious informed consent; Age older than 18 years. 18 years no limit Both Cholangitis Pancreatitis for other causes such as alcohol abuse, metabolic causes (hyperthermia or hypercalcemia), medication, trauma, etc. Chronic pancreatitis Pregnancy K85.1 Biliary acute pancreatitis Treatment - Drugs Placebo Intervention group: Diclofenac Suppository 100 mg every 8 hours will be added until symptom improvement and the day before surgery. Control group: Placebo Suppository every 8 hours will be added until the day before surgery. Mortality. Timepoint: End of the research. Method of measurement: Number of people. Organ failure. Timepoint: End of the research. Method of measurement: Lab test & physical exam. Necrotizing pancratitis. Timepoint: End of the research. Method of measurement: Abdominal & pelvic CT scan. Bacteremia. Timepoint: During the study. Method of measurement: Lab test. Cholangitis. Timepoint: During the study. Method of measurement: Lab test & physical exam. Need for necrozectomy surgery. Timepoint: During the study. Method of measurement: Abdominal & pelvic CT scan. Number of ICU & hospital admissions days. Timepoint: End of the research. Method of measurement: Number of days. Sanandaj University of Medical Sciences Approved 2017-05-01 Ethics committee of Kurdistan University of Medical Sciences Kowsar hospital, Pasdaran Blvd Sanandaj Kurdistan Iran (Islamic Republic of)