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IRCT20180520039739N2 IRCT 2018-11-26 Esfahan University of Medical Sciences Evaluation of effect of chlorhexidine on prevention of ventilator associated pneumonia Comparison of the effect of Chlorhexidine mouthwash with Dine mouthwash on prevention of ventilator-associated pneumonia in pediatric intensive care unit 2018-11-22 anticipated 80 Complete https://irct.ir/trial/34921 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization(random number table) : even numbers for Chlorhexidin and odds for Dine groups, Blinding description: The patients and their nurses are not aware of the kind of mouthwash and executor of plan will give the mouthwash to the nurses. 3 Ventilator associated pneumonia. Intervention 1: Intervention group: treatment with 10 cc of 0.2% chlorhexidine gluconate mouthwash (Emad darou company) 3 times per day for 5 days. Intervention 2: Intervention group: treatment with 20 drop of dine mouthwash (Dineh Iran) 3 times per day for 5 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public ‏Mohammadreza Habibzadeh
‏Hezarjerib Ave.
Esfahan Iran (Islamic Republic of) ندارد +98 913 389 1027 gsmhabibzadeh@yahoo.com Esfahan University of Medical Sciences scientific ‏Mohammadreza Habibzadeh
‏Hezarjerib Ave.
Esfahan Iran (Islamic Republic of) ندارد +98 913 389 1027 gsmhabibzadeh@yahoo.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Patients with age of 2 months to 14 years Patients who need mechanical ventilation for at least 48 hours Admission in pediatric intensive care unit 2 months 14 years Both Intubation before admission in PICU Oral or perioral lesions Immune deficiency Admission with causes of infectious or respiratory diseases Use of antibiotics before admission Sensitivity to herbal medication in past medical history Treatment - Drugs Treatment - Drugs Intervention group: treatment with 10 cc of 0.2% chlorhexidine gluconate mouthwash (Emad darou company) 3 times per day for 5 days Intervention group: treatment with 20 drop of dine mouthwash (Dineh Iran) 3 times per day for 5 days Incidence of pneumonia. Timepoint: In 5 days. Method of measurement: Infectious Diseases Society of America Guidelines and American Thoracic Society guidelines. Esfahan University of Medical Sciences Approved 2017-04-25 ‏Ethics committee of Esfahan university of medical sciences ‏Esfahan university of medical sciences , Hezarjerib Ave. Esfahan Isfehan Iran (Islamic Republic of)