IRCT20111009007745N10 IRCT 2021-09-19 Yasouj University of Medical Sciences The effect of combine fentanyl and midazolam on pain management and prevention of chronic pain ندارد The effect of Fentanyl and Midazolam on pain control and chronic pain prevention in patients with lower limb fracture 2021-09-06 anticipated 100 Complete https://irct.ir/trial/34918 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: does not have, Blinding description: Participants and health care personnel are not aware of the combination of injection drugs and health care personnel will not be involved in choosing patients. 2-3 Control of pain and prevention of chronic pain in patients with lower limb fracture. Intervention 1: Intervention group: Patients with lower limb fractures who are non-emergency candidates for surgery are selected. In the inpatient ward, informed consent is obtained to participate in the study. Numerical pain scale with a range of zero to ten) is given to the patient by the patient with the help of special emoticons describing the pain and a special ruler for this task. Then, at 5, 15 and 24 hours from the time of admission, the patient's pain intensity is evaluated and recorded. Patients are divided into two groups. The group that injects midazolam and fentanyl into the patient by infusion with a pump syringe starts from the time of hospitalization and continues up to 24 hours after the operation. Morphine is injected. Intervention 2: Control group: Control of pain in patients with lower limb fractures, these patients are given morphine if needed. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information available