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IRCT20161026030510N2 IRCT 2019-01-08 Iran University of Medical Sciences Deep Brain Stimulation for Treatment of Obsessive-Compulsive Disorder Investigation of Deep Brain Stimulation of Nucleus Accumbens for Treatment-Refractory Obsessive-Compulsive Disorder 2018-06-22 anticipated 5 Complete https://irct.ir/trial/34897 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 2 Condition 1: Obsessive-Compulsive Disorder. Condition 2: Cognitive performance. Deep brain stimulation (DBS), a neurosurgical procedure involving the implantation of a medical device called a neurostimulator, which sends electrical impulses, through implanted electrodes, to specific targets in the brain (nucleus accumbens) and stimulate this nucleus. After surgery, stimulation will be 130 Hz, at pulse widths of 90 and 150 us and at 2–7 V. Stimulation will adjust in optimization phase base on improvements of patients and clinical outcomes.. Yes - There is a plan to make this available What will be shared: Clinical and neuropsychological outcoms When: 2019 To whom: Academic Researchers Conditions: Academic Researchers Where to obtain: Email How to obtain: Academic Email Comments:
public Reza Arezoomandan
Shahied Mansuri St, Niayesh St, Sattarkhan Ave
Tehran Iran (Islamic Republic of) 14565-441 +98 21 6655 1656 arezoomandan.r@iums.ac.ir Iran University of Medical Sciences scientific Reza Arezoomandan
Shahid Mansuri St, Niayesh St, Sattarkhan Ave, Tehran, Iran
Tehran Iran (Islamic Republic of) 1445613111 +98 21 6655 1655 arezoomandan.r@iums.ac.ir Iran University of Medical Sciences Iran (Islamic Republic of) Age: 16-65 Diagnosis and Severity: Sever and chronic OCD for at least 5 years, Yale-Brown scale at least 25, Hamilton scale at least 17, IQ more than 85 Treatment refractoriness: Not response for SSRI for 12 weeks, clomipramine 12 weeks, atypical antipsychotics for 6 weeks and CBT for 16 seasons 18 years 65 years Both Psychotic disorders, bipolar disorder, autism disorder, substance abuse, epilepsy, dementia, Parkinson's disease and pregnancy F42 F99 Obsessive-compulsive disorder Diseases of the nervous system Treatment - Surgery Deep brain stimulation (DBS), a neurosurgical procedure involving the implantation of a medical device called a neurostimulator, which sends electrical impulses, through implanted electrodes, to specific targets in the brain (nucleus accumbens) and stimulate this nucleus. After surgery, stimulation will be 130 Hz, at pulse widths of 90 and 150 us and at 2–7 V. Stimulation will adjust in optimization phase base on improvements of patients and clinical outcomes. Severity of OCD. Timepoint: every month. Method of measurement: Yale- Brown scale. Neuropsychological performance. Timepoint: every month. Method of measurement: Neuropsychological tools. Side effects, such as headache, nausea and. Timepoint: during the intervention and 2 months after that. Method of measurement: questionnaire or observation. Iran University of Medical Sciences Approved 2018-11-24 Ethics committee of Iran University of Medical Sciences Shahid Hemmat Highway Tehran Tehran Iran (Islamic Republic of)