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IRCT20180428039443N1 IRCT 2019-01-07 Tehran University of Medical Sciences efficacy of erythrocyte transfusion in mortality rate of patients with aluminum phosphide Comparison of efficacy of erythrocyte transfusion in mortality rate of patients with aluminum phosphide contamination with coservative treatmnt: A study of randomized clinical trials 2018-10-23 anticipated 140 Complete https://irct.ir/trial/34658 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Baharlou Hospital is a medical, research and therapeutic center under the cover of Tehran University of Medical Sciences in southern Tehran, which has dominated various specialized clinics including internal, surgical, pediatric, neurological, neurosurgical, eye, cardiology, etc. It is the special poisoning center of Tehran University Medical Sciences.In this study, a number of patients who had been poisoned with Aluminum Phosphide and referred to Baharlo Hospital and admitted to the ICU were divided into two groups of intervention and comparison: Group 1 or intervention: Patients who receive standard RBC transfusion in addition to standard transfusion.Group 2 or Comparison: Patients undergoing standard treatment and Transfusion do not receive RBC fresh packed.At first, the age, sex, marital status and occupation of patients will be recorded and will be recorded in the hospital, Randomization description: The random number sequences of volunteers are made by the Sealed Envelope | Randomization site. Using random quadrilateral blocks, the random chain is created at first by the number of sample volumes, Blinding description: Because of the nature of the outcome of the disease (death), blindness or blindness does not disclose the study. However, the final data for analysis will be coded and analyzed without the knowledge of the treatment group. Data collection authorities and those who evaluate the outcome, Data Safety and Monitoring Committee, and those who prepare the draft article, are kept blind to the studied groups. N/A aluminium phosphide poisoning. Intervention 1: Intervention group: Patients who receive, in addition to standard treatment, fresh packed RBC transfusion (transmitted by the blood transfusion center). Intervention 2: Control group: Patients undergoing standard treatment and not receiving fresh packed RBC transfusion. Yes - There is a plan to make this available What will be shared: All patient information documented data without identification. The information entered will eventually be entered in the database of the database. When: Data will be available upon national and international patenting process completion of the study. To whom: All interested researchers Conditions: There is no specific condition. Where to obtain: Dr. Ahmad Reza Dehpour How to obtain: The procedure outlined by the Ethics Committee of Tehran University of Medical Sciences. Comments:
public Ahmad Reza Dehpour
Poursina St.
Tehran Iran (Islamic Republic of) 1417613151 +98 21 8897 3652 dehpoura@sina.tums.ac.ir Tehran University of Medical Sciences scientific Ahmad Reza Dehpour
Department of Pharmacology, Tehran University of Medical Sciences, Poursina Street
Tehran Iran (Islamic Republic of) 1417613151 +98 21 8897 3652 dehpoura@sina.tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Age over 18 years More than 1/4 tablets of rice (aluminum phosphide) They have not been poisoned for more than 4 hours. Clinical manifestations (garlic smell, hypotension (less than 60/100 mm / Hg), gastrointestinal tract pain (retinoestromem, vomiting) Laboratory disorder including metabolic acidosis (less than 7.2) 18 years no limit Both People who have taken herbal pill (Banana). History of any known chronic disease (high hemoglobin, congestive failure) due to clinical diagnosis. pregnant women lactating woman History of response to blood transfusion Patients with CHF (do not have transfusion bearing erythrocyte) Patients with hemoglobin above 16 T60 Toxic effect of pesticides Treatment - Other Treatment - Other Intervention group: Patients who receive, in addition to standard treatment, fresh packed RBC transfusion (transmitted by the blood transfusion center). Control group: Patients undergoing standard treatment and not receiving fresh packed RBC transfusion. Metabolic acidosis,. Timepoint: The moment of arrival, one hour after arrival, two hours after arrival, three hours after arrival, six hours after arrival, twelve hours after arrival, twelve and four hours after arrival, forty eight hours after arrival, seventy And hours after arrival. Method of measurement: Metabolic acidosis is estimated by measuring the level of acidity in the blood. Mortality rate. Timepoint: From the time of arrival to the moment of discharging from the hospital. Method of measurement: The mortality rate is also obtained by the number of treated patients compared to the referrals. Tehran University of Medical Sciences Approved 2018-11-20 Ethics committee of Tehran University of Medical Sciences Poursina St. Tehran Tehran Iran (Islamic Republic of)