IRCT20121216011763N35 IRCT 2018-10-28 Esfahan University of Medical Sciences synbiotic and hypothyroidism The effect of synbiotic supplementation on anthropometric indices, Inflammatory and hormone profiles in patients with hypothyroidism 2018-11-06 anticipated 56 Complete https://irct.ir/trial/34286 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Randomly, based on the permuted block randomization method, using blocks of 4 that will be blocked based on gender variables and will be assigned to one of two synbiotic and placebo groups.The enrolling participants, and assigning participants to the groups will carried out by a trained nutritionist. Researchers will not informed about randomization process until completion of data analyses, Blinding description: This study is a double-blind clinical trial (participant, researcher). The familact synbiotic supplement and its placebo will be produce by Zist takhmir company . Synbiotic supplement and its placebos will in the same form of package and the patients and researcher will not aware of the content of the pack until the end of trial. N/A Hypothyroidism. Intervention 1: Intervention group: A daily dose of 500 mg of FimiLact synbiotic capsule was read 2 hours after Levothyroxine tablet for 8 weeks (dosage of 1 capsule per day). Synthetic FamiLact Synthetic Foam Supplement will be manufactured by Iranian Zist Takhmir Company. Intervention 2: Control group: Each day, 1 placebo (starch 375 mg, lactose 22 mg, magnesium stearate 1 mg, 1 mg silicon dioxide, 1 mg talc) will receive 2 hours after levothyroxine for 8 weeks.The placebo will be made by Tehran Zist Takhmir Company. Yes - There is a plan to make this available What will be shared: The collected deidentified for the primary outcome measure only will be shared. When: starting 12 months after publication. To whom: Available for people working in academic institutions Conditions: The data will provide for educational use. Where to obtain: Dr. Gholamreza Askari askari@mui.ac.ir How to obtain: The data will send as soon as possible, after receiving the request. Comments: