IRCT20180915041040N1 IRCT 2018-11-30 Esfahan University of Medical Sciences weaning from nasal continuous positive airway pressure in preterm infants Comparing sudden Complete and gradual weaning on successful weaning from nasal CPAP in preterm infants 2014-11-03 anticipated 60 Complete https://irct.ir/trial/33859 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: simple randomization Using random numbers table, Blinding description: Single blind. Parents of neonates were kept unaware of the groups their neonate was allocate to. N/A Respiratory distress syndrome of newborn. Intervention 1: Intervention group: infant is separated from NCPAP and is allowed to breathe in the room air with FiO2 of 21% or with extra oxygen with FiO2 of 40% for 4 hours. Then, NCPAP with 5 cm H2O PEEP and FiO2 of 21% is applied for 6 hours. Under a stable clinical condition over the 6 hours, weaning is performed and the duration of separation is increased every 4 hours up to 12 hours. The duration of NCPAP between weaning intervals will be constant, i.e., 6 hours. In the next step, when the infant is weaned for 12 hours and no criteria of treatment failure is occurred, NCPAP is continued for additional 6 hours and then, the infant is completely weaned. Intervention 2: Control group: sudden complete weaning, the infant is separated completely from the set and is allowed to breathe in room air (FiO2 = 21%) or with extra oxygen with FiO2 of maximally 40%. No - There is not a plan to make this available Justification or reason for not sharing IPD is "There is no more information."