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IRCT20120524009844N6 IRCT 2019-04-08 Tabriz University of Medical Sciences Evaluation of intralesional injection and multipuncture of bleomycin in resistant palmaplanter Warts Comparison of combination of crayotherapy & multipuncture intralesional injection of bleomycin and cryotherapy alone in treatment of resistant palmaplanter Warts 2019-04-21 anticipated 60 Complete https://irct.ir/trial/33722 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: A simple randomization will be carried out on an individual basis by RandList software. The allocation will be sealed by an independent monitor and will not be broken until the end of the study, Blinding description: The investigator assessing outcome and analyzing the data will be blinded to treatment allocation until the end of the study. 3 resistant palmaplanter Warts. Intervention 1: Intervention group: Cryotherapy and intraleisional injection of bleomycin. In the intervention group, 30 patients with palmoplantar warts will be treated with cryotherapy in combination with intraleisional injection of bleomycin (1 mg/ml) at the start of the study, and in case of failure at weeks 3 and 6 of the study. Intervention 2: Control group: Only cryotherapy In the control group, 30 patients with palmoplantar warts will be treated with cryotherapy at the onset of the study and in case of failure, in the third and sixth weeks of the study. Yes - There is a plan to make this available What will be shared: All data will be shared after being unidentified. When: At any time To whom: It will be free for everyone. Conditions: There are no special conditions Where to obtain: Email: mehamir46@gmail.com Dr Mehdi Amirnia 09143113577 Dermatology Department - Sina Hospital- Azadi Street- Tabriz How to obtain: The Request will be checked, then data will be sent by Email in 1 month. Comments:
public دکتر مهدی امیرنیا
Sina Hospital, Azadi Street, Tabriz
Tabriz Iran (Islamic Republic of) 516369888 +98 41 3549 8236 mehamir46@gmail.com Tabriz University of Medical Sciences scientific Dr. Mehdi Amirnia
Sina Hospital, Azadi Street, Tabriz
Tabriz Iran (Islamic Republic of) 516369888 +98 41 3549 8236 mehamir46@gmail.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Patients with palmoplantar wart resistant to treatment Have disease for more than 2 years Patients with age range of 18- 50 years old 18 years 50 years Both Patients with Injection phobia Patients with Raynaud or Rheumatologic disorder history Patients with allergy to local anesthetics B07 Viral warts Treatment - Other Treatment - Other Intervention group: Cryotherapy and intraleisional injection of bleomycin. In the intervention group, 30 patients with palmoplantar warts will be treated with cryotherapy in combination with intraleisional injection of bleomycin (1 mg/ml) at the start of the study, and in case of failure at weeks 3 and 6 of the study. Control group: Only cryotherapy In the control group, 30 patients with palmoplantar warts will be treated with cryotherapy at the onset of the study and in case of failure, in the third and sixth weeks of the study. Numbers of Warts. Timepoint: weeks 0,3,6 and 9. Method of measurement: Counting. Diameter of the largest wart. Timepoint: Weeks 0,3,6,9. Method of measurement: Measure by ruler. Improvement. Timepoint: Weeks 3, 6, 9. Method of measurement: Observation. Probable side effects. Timepoint: Weeks 3, 6, 9. Method of measurement: Observation. Disease relapse. Timepoint: weeks 3, 6, 9. Method of measurement: Observation. Tabriz University of Medical Sciences Approved 2018-12-12 Ethics committee of Tabriz University of Medical Sciences Sina Hospital, Azadi street, Tabriz Tabriz East Azarbaijan Iran (Islamic Republic of)