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IRCT20180826040866N1 IRCT 2018-11-15 Mashhad University of Medical Sciences Evaluation the efficacy of orthodontic adhesive containing titanium dioxide and chitosan nano-particles in fixed orthodontic patients Evaluation the effect of orthodontic adhesive containing titanium dioxide and chitosan nano-particles on mineral content and streptococcus mutans population in fixed orthodontic patients 2019-02-20 anticipated 50 Complete https://irct.ir/trial/33462 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Method of randomization will be simple and will be accomplished using the table of random numbers. Allocation concealment will be achieved with sequentially numbered, opaque, sealed envelopes containing the treatment allocation cards. Baseline information will be written on the outside before opening the envelope. The project manager will be responsible for opening the next envelope in sequence and implementing the randomization process, Blinding description: The patients do not know that they are in the control group or the intervention group and the composites used in tubes with the same and encoded shapes that the clinician does not know about. Finally, the sampling is also coded to allow the data analyzer to be blinded to the study. 3 Demineralization of tooth enamel. Intervention 1: Intervention group: In this group, for bonding brackets the composite (Transbond XT, 3M, USA), which adds 5% by weight of titanium dioxide nanoparticles and 5% by weight of nanochitosan will be used. Intervention 2: Control group: In this group, for bonding of brackets the composite (Transbond XT, 3M, USA) will be used. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Fahimeh Farzanegan
Vakilabad blvd, Park Square, Mashhad Dental School
Mashhad Iran (Islamic Republic of) 9185836393 +98 51 3882 9501 farzaneganf@mums.ac.ir Mashhad University of Medical Sciences scientific Fahimeh Farzanegan
Vakilabad blvd, Park Square, Mashhad Dental School
Mashhad Iran (Islamic Republic of) 9185836393 +98 51 3882 9501 farzaneganf@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Orthodontic patients aged between 13-18 years undergoing fixed orthodontic treatment Healthy gum Upper second premolars and upper lateral incisors of the participants to be free of macroscopic enamel cracks, caries, or enamel hypoplasia. 13 years 18 years Both Patients taking medications that cause xerostomia. Systemic disease or active periodontal disease Active caries on at least one tooth Prevention Prevention Intervention group: In this group, for bonding brackets the composite (Transbond XT, 3M, USA), which adds 5% by weight of titanium dioxide nanoparticles and 5% by weight of nanochitosan will be used. Control group: In this group, for bonding of brackets the composite (Transbond XT, 3M, USA) will be used. Population of Sterptococcus Mutans. Timepoint: 24 hours, 2 months and 6 months after placing brackets. Method of measurement: Real-time polymerase chain reaction. ِDetermination of mineral context of enamel. Timepoint: 24 hours, 2 months and 6 months after placing brackets. Method of measurement: Quantitative laser fluorescence technique. Mashhad University of Medical Sciences Approved 2018-09-23 Ethics committee of Mashhad University of Medical Sciences Azadi Square, Mashhad Dental School Mashhad Razavi Khorasan Iran (Islamic Republic of)