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IRCT20180806040721N1 IRCT 2018-10-03 Shahroud University of Medical Sciences Comparison of the effect of 8 weeks of different training (aerobic, resistance and combination) on serum levels of nesfatin-1 and insulin resistance index in women with type 2 diabetes Comparison of the effect of 8 weeks of different training (aerobic, resistance and combination) on serum levels of nesfatin-1 and insulin resistance index in women with type 2 diabetes 2017-07-02 anticipated 60 Complete https://irct.ir/trial/33114 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Diabets. Intervention 1: Intervention group: Aerobic training group Participants of this group performed their activities using treadmill or bicycle three times per week (on non consecutive days). Time of exercise was increased from 20 minutes per session (at 60% of maximum heart rate) to 60 minutes (at 75% of maximum heart rate) per session. Heart rate was regularly determined by the monitor’s treadmill or cycle ergometers. Required heart rate was calculated by the Karvonen formula. Intervention 2: Intervention group: Resistance training group This program was performed on different weight machines. Correct training techniques were instructed and supervised by professional trainers. The protocol was started on 2 days of the week during the first month and was increased to 3 non-consecutive days per week. Training was started during weeks 1 and 2 with intensity 60% onerepetition maximum (1RM) and was progressed to intensity 75-80% 1RM. The number of sets was 1-2 during the first month. This program included 10 different exercises for upper and lower body. Participants performed 3 sets of 8-10 repetitions (with a 90- 120 s rest between sets) of the following exercises: bench press, seated row, shoulder press, chest press, lateral pulldown, abdominal crunches, leg press, leg extension, triceps pushdown and seated bicep curls. Intervention 3: Intervention group: Combined training group (aerobic-resistance) The subjects of this group did the aerobic exercise plus resistance training programs 3 times a week. After a warm-up stage, they worked for 20-30 minutes on a treadmill or bicycle plus 2 sets of each of 8 exercises with 8-10 repetitions on weight machines. Intervention 4: control group:control group A group that did not have any training intervention. No - There is not a plan to make this available Justification or reason for not sharing IPD is The epidemic is the consent of the participants to disseminate their information and data
public Dianatinasab Mostafa
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Shahrood Iran (Islamic Republic of) 71-535121 +98 23 3223 4521 dianati.epid@yahoo.com Shahroud University of Medical Sciences Iran (Islamic Republic of) The inclusion criteria were: having been suffering from T2DM (fasting blood sugar ≥126 mg/dl and 2-hour postprandial blood glucose ≥200 mg/dl) for at least 2 years; old Women 45 to 60 years 45 years 60 years Female exclusion criteria: diagnosed with any other diseases E08 Diabetes mellitus due to underlying condition Treatment - Devices Treatment - Devices Treatment - Devices N/A Intervention group: Aerobic training group Participants of this group performed their activities using treadmill or bicycle three times per week (on non consecutive days). Time of exercise was increased from 20 minutes per session (at 60% of maximum heart rate) to 60 minutes (at 75% of maximum heart rate) per session. Heart rate was regularly determined by the monitor’s treadmill or cycle ergometers. Required heart rate was calculated by the Karvonen formula Intervention group: Resistance training group This program was performed on different weight machines. Correct training techniques were instructed and supervised by professional trainers. The protocol was started on 2 days of the week during the first month and was increased to 3 non-consecutive days per week. Training was started during weeks 1 and 2 with intensity 60% onerepetition maximum (1RM) and was progressed to intensity 75-80% 1RM. The number of sets was 1-2 during the first month. This program included 10 different exercises for upper and lower body. Participants performed 3 sets of 8-10 repetitions (with a 90- 120 s rest between sets) of the following exercises: bench press, seated row, shoulder press, chest press, lateral pulldown, abdominal crunches, leg press, leg extension, triceps pushdown and seated bicep curls Intervention group: Combined training group (aerobic-resistance) The subjects of this group did the aerobic exercise plus resistance training programs 3 times a week. After a warm-up stage, they worked for 20-30 minutes on a treadmill or bicycle plus 2 sets of each of 8 exercises with 8-10 repetitions on weight machines control group:control group A group that did not have any training intervention. Nesfatin-1. Timepoint: At the beginning of the study (before the intervention) and 2 months after the intervention, it was measured. Method of measurement: The serum level of nesfatin-1 was measured using the Sandwich Elisa method and using the Eastbiopharm human kit / country-China manufacturing. Insulin resistance index. Timepoint: At the beginning of the study (before the intervention) and 2 months after the intervention, it was measured. Method of measurement: Insulin resistance index using formula = fasting insulin (μU / ml) × fasting glucose (mmol / L) / 22.5. Glocose/ Insulin- Insulin resistance. Timepoint: At the beginning of the study (before the intervention) and 2 months after the intervention, it was measured. Method of measurement: The glucose level was measured using the Colorimetric Enzymatic method and using the human kit of Iran Pars Tesh T Persian Company.  Insulin levels were measured by Insulin ELISA in the United States. Insulin resistance with the formula: fasting glucose (mmol / L) * fasting insulin (μU / ml)/ 22/5. Shahroud University of Medical Sciences Approved 2018-07-22 Shahroud University of Medical Sciences Tehran street Shahroud Semnan Iran (Islamic Republic of)