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IRCT201202183236N2 IRCT 2012-03-07 Vice chancellor for research OF Shiraz university of medical sciences Effect of pomegranate supplement on Rheumatoid Arthritis patients The effect of pomegranate extract on clinical index, inflammation markers and oxidative stress of Rheumatoid Arthritis patient in 1390 2011-11-22 anticipated 50 Complete https://irct.ir/trial/3309 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive. N/A Condition 1: Rheumatoid arthritis. Condition 2: Rheumatoid arthritis. Intervention 1: Placebo(2 capsules) intake per day, for 2 months. Intervention 2: Pomegranate supplement(2 capsules) intake is equivalent to 500 mg per day, for 2 months.
public Elham Tavakoli
Department of nutrition, School of health & nutrition,Shiraz University of Medical Sciences
Shiraz Iran (Islamic Republic of) +98 71172510018 elham1tavakoli@yahoo.com School of health & nutrition, Shiraz University of Medical Sciences scientific Dr.Zohreh Mazloom
Department of nutrition, School of health & nutrition, Shiraz University of Medical Sciences
Shiraz Iran (Islamic Republic of) +98 71172510018 zmazloom@sums.ac.ir School of health & nutrition, Shiraz University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: Rheumatoid arthritis patients which their disease diagnosed according to the revised American Rheumatism Association criteria, ages between 18-65 years old, RA patients who don’t have enough clinical and laboratory response to conventional disease modifying anti rheumatic drugs (Methotrexate, Hydroxychloroquine, Sulphasalazine, and prednisolone), No drug type and dose fluctuation since 1 month prior to the study and during intervention period. Exclusion criteria: Presence of Chronic disease such as diabetes, cardiovascular, hepatic, kidney, gastrointestinal diseases, and severe infection, smoking, Alcohol consumption, use of supplements (antioxidants, multivitamins,...), patients with known allergy and food intolerance. 18 years 65 years Both M06 M05 Other rheumatoid arthritis Seropositive rheumatoid arthritis Placebo Treatment - Drugs Placebo(2 capsules) intake per day, for 2 months Pomegranate supplement(2 capsules) intake is equivalent to 500 mg per day, for 2 months Disease activity. Timepoint: Before and 2 months after intervention. Method of measurement: DAS 28. Disability and Pain scales. Timepoint: Before and 2 months after intervention. Method of measurement: health Assessment Questionnaire for Rheumatoid Arthritis patients. Duration of morning stiffness. Timepoint: Before and 2 months after intervention. Method of measurement: Taking history and Questionnaire. Glutathione peroxidase. Timepoint: Before and 2 months after intervention. Method of measurement: ELIZA kit. MDA. Timepoint: Before and 2 months after intervention. Method of measurement: Spectrophotometry. CRP. Timepoint: Before and 2 months after intervention. Method of measurement: ELIZA kit. ESR. Timepoint: Before and 2 months after intervention. Method of measurement: Westergren. MMP3. Timepoint: Before and 2 months after intervention. Method of measurement: ELIZA kit. Vice chancellor for research OF Shiraz university of medical sciences Approved 2011-11-19 Shiraz University of Medical Sciences Central Medical Building, Zand Avenue, PO Box 1978-71345 shiraz Iran (Islamic Republic of)