IRCT20180718040514N1 IRCT 2019-03-12 Tehran University of Medical Sciences The effect of Vit D on AMH level and ovarian reserve in 18-40 years old female breast cancer patients who have been treated with chemotherapy between 1397-1398 in Imam Khomeini hospital. The effect of Vit D on AMH level and ovarian reserve in female breast cancer patients who have been treated with chemotherapy 2018-11-27 anticipated 40 Complete https://irct.ir/trial/33028 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Referred patients are randomized to 2 groups.One receive daily vit D (1000 IU) and other group receive no drug, Blinding description: The analysers are not informed about randomization groups, ,patients and analyser are informed due to lack of placebo in study. 3 Infertility due to breast cancer chemotherapy.. Intervention 1: In this study 18-40 years old female breast cancer patients will be randomized in 2 groups. patients with history of cytotoxic therapy or BSO will be excluded.age,number of pregnancies, fertility status,menstrual disorders, smoking history, type of surgery and cancer stage will be documented.Before chemotherapy,AMH level will be documented for all patients. One group will be administered with 1000 IU daily calciteriol during and till six month after chemotherapy.The second group will not take vitamin D.The AMH level falls immediately after chemotherapy and will gradually improved during chemotherapy and fully recover after 3-6 month of chemotherapy.The AMH level will be measured before, at the end and 6 month after chemotherapy. all measurements will be in the same lab and with the same manner. Intervention 2: Control group: the group that receive no drug. No - There is not a plan to make this available Justification or reason for not sharing IPD is Not to diminish patients data.