IRCT20090613002027N15 IRCT 2019-08-26 Mazandaran University of Medical Sciences ٍEffect of amilodipine on heart function and cardiac iron deposition in β-thalassemia patients Evaluation of the effect of amilodipine on heart function and cardiac iron deposition in β-thalassemia patients: A randomized double blind crosss-over study 2019-01-10 anticipated 62 Complete https://irct.ir/trial/33014 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Treatment, Randomization description: Stratified randomization will be performed for patients based on MRI before enrollment in the study [MRI T2 of 10 to 15 milliseconds (moderate iron deposition in the heart) and MRI T2 of less than 10 milliseconds (severe iron deposition in the heart). ٌWhether the patient receives first Amlodipine then Placebo or first Placebo then Amlodipine will be determined by block randomization with 4 cases in each block. Drugs and placebo will be put in containers with the same shape. The patients and the physician will not be aware of the group they are assigned to, Blinding description: A separate 5-digit code obtained from the computer will be assigned to each patient.The intervention, including the drug or placebo, will be placed in identical containers, and the senior researcher will insert the code on the containers. The researcher and patient will not be aware of the type of intervention received. 2 β-thalassemia. Intervention 1: Intervention group: amlodipine tablets 5 mg daily for 6 months. Intervention 2: Control group: Amlodipine placebo daily for 6 months. No - There is not a plan to make this available Justification or reason for not sharing IPD is Confidentiality of patients data